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• W2041133047 startingPage "380" @default.
• W2041133047 abstract "Pigs were injected intramuscularly (i.m.) twice with human serum albumin (HSA) with or without 1alpha,25-dihydroxyvitamin D3[1alpha,25(OH)2D3] with a 5-week interval. The supplementation of 1alpha,25(OH)2D3 enhanced the HSA-specific IgA serum antibody response but decreased the IgM, IgG, IgG1 and IgG2 responses. Furthermore, higher numbers of HSA-specific IgA antibody-secreting cells were obtained in systemic lymphoid tissues (local draining lymph node, spleen and bone marrow) as well as in Peyer's patches and lamina propria of the gut (GALT). In addition, the in vivo mRNA expression for Th1 [interferon (IFN)-gamma, interleukin (IL-2)], Th2 (IL-4, IL-6 and IL-10) and Th3 [transforming growth factor (TGF)-beta] cytokines as well as the percentage of different cell subsets (CD2+, CD4+, CD8+, IgM+, MHC II+, CD25+) of monomorphonuclear cells from the local draining lymph node were determined at different time-points after the i.m. immunizations. Cytokine profiles did not resemble a typical Th-cytokine profile using 1alpha,25(OH)2D3: higher levels of IL-10 and significantly lower levels of IL-2 were observed the first day after the primary immunization. However, significantly higher levels of IL-2 and significantly lower levels of IFN-gamma were observed the first day after the second immunization. Furthermore, after the second immunization TGF-beta mRNA expression decreased more quickly in the 1alpha,25(OH)2D3 group. This difference became significant 7 days after the second immunization. One week later a significantly higher percentage of CD25+ cells was observed in this group, indicating more activated T and B cells using the steroid hormone. These results suggest that in pigs the addition of 1alpha,25(OH)2D3 to an intramuscularly injected antigen can enhance the antigen-specific IgA-response and prime GALT tissues, but the relation with cytokines and cell phenotype in the local draining lymph node needs further clarification." @default.
• W2041133047 created "2016-06-24" @default.
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• W2041133047 date "2004-02-05" @default.
• W2041133047 modified "2023-09-24" @default.
• W2041133047 title "1<i>α</i>, 25-dihydroxyvitamin D3 increases IgA serum antibody responses and IgA antibody-secreting cell numbers in the Peyer's patches of pigs after intramuscular immunization" @default.
• W2041133047 cites W1505099461 @default.
• W2041133047 cites W1529226217 @default.
• W2041133047 cites W1552925034 @default.
• W2041133047 cites W158105621 @default.
• W2041133047 cites W1598047674 @default.
• W2041133047 cites W1602751534 @default.
• W2041133047 cites W1625897096 @default.
• W2041133047 cites W1627068912 @default.
• W2041133047 cites W1657528050 @default.
• W2041133047 cites W173598149 @default.
• W2041133047 cites W1885898936 @default.
• W2041133047 cites W1968637844 @default.
• W2041133047 cites W1968878008 @default.
• W2041133047 cites W1968972754 @default.
• W2041133047 cites W1970959631 @default.
• W2041133047 cites W1971203081 @default.
• W2041133047 cites W1972922050 @default.
• W2041133047 cites W1974972571 @default.
• W2041133047 cites W1975876211 @default.
• W2041133047 cites W1977162639 @default.
• W2041133047 cites W1977655619 @default.
• W2041133047 cites W1978104445 @default.
• W2041133047 cites W1978214647 @default.
• W2041133047 cites W1982485436 @default.
• W2041133047 cites W1984321198 @default.
• W2041133047 cites W1986841282 @default.
• W2041133047 cites W1993383273 @default.
• W2041133047 cites W1996928607 @default.
• W2041133047 cites W1998427300 @default.
• W2041133047 cites W2001562785 @default.
• W2041133047 cites W2006083207 @default.
• W2041133047 cites W2007388283 @default.
• W2041133047 cites W2007682045 @default.
• W2041133047 cites W2007751085 @default.
• W2041133047 cites W2008774104 @default.
• W2041133047 cites W2009286881 @default.
• W2041133047 cites W2009437149 @default.
• W2041133047 cites W2010358333 @default.
• W2041133047 cites W2015376750 @default.
• W2041133047 cites W2017683434 @default.
• W2041133047 cites W2018868619 @default.
• W2041133047 cites W2021264322 @default.
• W2041133047 cites W2027925603 @default.
• W2041133047 cites W2031524213 @default.
• W2041133047 cites W2036088433 @default.
• W2041133047 cites W2037287388 @default.
• W2041133047 cites W2047366897 @default.
• W2041133047 cites W2050892914 @default.
• W2041133047 cites W2056558184 @default.
• W2041133047 cites W2066669003 @default.
• W2041133047 cites W2073544400 @default.
• W2041133047 cites W2073871743 @default.
• W2041133047 cites W2079357214 @default.
• W2041133047 cites W2079401513 @default.
• W2041133047 cites W2082213876 @default.
• W2041133047 cites W2083373216 @default.
• W2041133047 cites W2084422760 @default.
• W2041133047 cites W2094346465 @default.
• W2041133047 cites W2101781154 @default.
• W2041133047 cites W2108825111 @default.
• W2041133047 cites W2109082501 @default.
• W2041133047 cites W2110527323 @default.
• W2041133047 cites W2120478433 @default.
• W2041133047 cites W2122009846 @default.
• W2041133047 cites W2124961779 @default.
• W2041133047 cites W2129148017 @default.
• W2041133047 cites W2129379081 @default.
• W2041133047 cites W2143565640 @default.
• W2041133047 cites W2150863194 @default.
• W2041133047 cites W2151176594 @default.
• W2041133047 cites W2156575334 @default.
• W2041133047 cites W2418960513 @default.
• W2041133047 cites W4313343349 @default.
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• W2041133047 doi "https://doi.org/10.1111/j.1365-2249.2003.02377.x" @default.
• W2041133047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1808982" @default.
• W2041133047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15008969" @default.
• W2041133047 hasPublicationYear "2004" @default.
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