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• W2041161369 abstract "UMP kinase (PyrH) is an essential enzyme found only in bacteria, making it ideal as a target for the discovery of antibacterials. To identify inhibitors of PyrH, an assay employing Staphylococcus aureus PyrH coupled to pyruvate kinase/lactate dehydrogenase was developed and was used to perform a high throughput screen. A validated aminopyrimidine series was identified from screening. Kinetic characterization of this aminopyrimidine indicated it was a competitive inhibitor of ATP. We have shown that HTS can be used to identify potential leads for this novel target, the first ATP competitive inhibitor of PyrH reported." @default.
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• W2041161369 date "2013-07-01" @default.
• W2041161369 modified "2023-10-07" @default.
• W2041161369 title "Screening-based discovery of the first novel ATP competitive inhibitors of the Staphylococcus aureus essential enzyme UMP kinase" @default.
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• W2041161369 doi "https://doi.org/10.1016/j.bbrc.2013.06.060" @default.
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