Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041163519> ?p ?o ?g. }
- W2041163519 endingPage "286" @default.
- W2041163519 startingPage "280" @default.
- W2041163519 abstract "The first step of the purine de novo synthesis pathway is catalyzed by amidophosphoribosyltransferase (E.C.2.4.2.14) which is encoded by two Prat genes in D. melanogaster, Prat and Prat2. Prat is a retrogene duplication of Prat2, where each gene has a distinct expression pattern. Prat transcription is restricted to proliferating tissues such as imaginal discs and the female germ line. Three conserved putative DNA replication-related element binding factor (DREF) sites lie upstream of the Prat coding region. These elements are upstream of many genes important in cell proliferation. We have found that DREF binds directly upstream of Prat and that the DRE sites associated with its activity are necessary for Prat expression; furthermore, we have determined that a second cis-acting element is present upstream of the Prat gene. Finally, the genes Distal-less, Mi-2 and dMyc, which influence Dref activity, do not appear to affect Prat transcription." @default.
- W2041163519 created "2016-06-24" @default.
- W2041163519 creator A5009091756 @default.
- W2041163519 creator A5063966446 @default.
- W2041163519 creator A5076834412 @default.
- W2041163519 date "2013-04-01" @default.
- W2041163519 modified "2023-09-27" @default.
- W2041163519 title "Transcriptional regulation of the purine de novo synthesis gene Prat in Drosophila melanogaster" @default.
- W2041163519 cites W1525724146 @default.
- W2041163519 cites W1579310140 @default.
- W2041163519 cites W1932107019 @default.
- W2041163519 cites W1969890525 @default.
- W2041163519 cites W1970321798 @default.
- W2041163519 cites W1976519371 @default.
- W2041163519 cites W1980333298 @default.
- W2041163519 cites W1982656482 @default.
- W2041163519 cites W1985027918 @default.
- W2041163519 cites W1991474211 @default.
- W2041163519 cites W1992995602 @default.
- W2041163519 cites W1993827187 @default.
- W2041163519 cites W1997202813 @default.
- W2041163519 cites W2006417558 @default.
- W2041163519 cites W2016021790 @default.
- W2041163519 cites W2017641297 @default.
- W2041163519 cites W2021482536 @default.
- W2041163519 cites W2022993325 @default.
- W2041163519 cites W2026536691 @default.
- W2041163519 cites W2046573194 @default.
- W2041163519 cites W2048002730 @default.
- W2041163519 cites W2049181112 @default.
- W2041163519 cites W2049807410 @default.
- W2041163519 cites W2059238135 @default.
- W2041163519 cites W2060930539 @default.
- W2041163519 cites W2066620514 @default.
- W2041163519 cites W2075215600 @default.
- W2041163519 cites W2084191969 @default.
- W2041163519 cites W2097353028 @default.
- W2041163519 cites W2097774235 @default.
- W2041163519 cites W2099762535 @default.
- W2041163519 cites W2102209253 @default.
- W2041163519 cites W2105288217 @default.
- W2041163519 cites W2106895159 @default.
- W2041163519 cites W2108244474 @default.
- W2041163519 cites W2108569257 @default.
- W2041163519 cites W2110643873 @default.
- W2041163519 cites W2115333309 @default.
- W2041163519 cites W2123017585 @default.
- W2041163519 cites W2125671857 @default.
- W2041163519 cites W2126248599 @default.
- W2041163519 cites W2129783899 @default.
- W2041163519 cites W2132926880 @default.
- W2041163519 cites W2136583745 @default.
- W2041163519 cites W2149548143 @default.
- W2041163519 cites W2151029758 @default.
- W2041163519 cites W2152719313 @default.
- W2041163519 cites W2157009395 @default.
- W2041163519 cites W2157028755 @default.
- W2041163519 cites W2163965551 @default.
- W2041163519 cites W2170844841 @default.
- W2041163519 cites W2171742268 @default.
- W2041163519 cites W597093558 @default.
- W2041163519 doi "https://doi.org/10.1016/j.gene.2013.01.024" @default.
- W2041163519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23357222" @default.
- W2041163519 hasPublicationYear "2013" @default.
- W2041163519 type Work @default.
- W2041163519 sameAs 2041163519 @default.
- W2041163519 citedByCount "2" @default.
- W2041163519 countsByYear W20411635192014 @default.
- W2041163519 countsByYear W20411635192018 @default.
- W2041163519 crossrefType "journal-article" @default.
- W2041163519 hasAuthorship W2041163519A5009091756 @default.
- W2041163519 hasAuthorship W2041163519A5063966446 @default.
- W2041163519 hasAuthorship W2041163519A5076834412 @default.
- W2041163519 hasConcept C104317684 @default.
- W2041163519 hasConcept C138885662 @default.
- W2041163519 hasConcept C165864922 @default.
- W2041163519 hasConcept C179926584 @default.
- W2041163519 hasConcept C21592294 @default.
- W2041163519 hasConcept C2776998849 @default.
- W2041163519 hasConcept C2780104201 @default.
- W2041163519 hasConcept C41895202 @default.
- W2041163519 hasConcept C54355233 @default.
- W2041163519 hasConcept C7602840 @default.
- W2041163519 hasConcept C86803240 @default.
- W2041163519 hasConceptScore W2041163519C104317684 @default.
- W2041163519 hasConceptScore W2041163519C138885662 @default.
- W2041163519 hasConceptScore W2041163519C165864922 @default.
- W2041163519 hasConceptScore W2041163519C179926584 @default.
- W2041163519 hasConceptScore W2041163519C21592294 @default.
- W2041163519 hasConceptScore W2041163519C2776998849 @default.
- W2041163519 hasConceptScore W2041163519C2780104201 @default.
- W2041163519 hasConceptScore W2041163519C41895202 @default.
- W2041163519 hasConceptScore W2041163519C54355233 @default.
- W2041163519 hasConceptScore W2041163519C7602840 @default.
- W2041163519 hasConceptScore W2041163519C86803240 @default.
- W2041163519 hasIssue "2" @default.
- W2041163519 hasLocation W20411635191 @default.
- W2041163519 hasLocation W20411635192 @default.