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- W2041195700 abstract "A novel gene that regulates the α-toxin (plc), κ-toxin (colA), and θ-toxin (pfoA) genes was identified using toxin-negative mutant strains of Clostridium perfringens. The cloned 3.2-kb fragment contained the virX gene encoding a 51-amino acid polypeptide of unknown function that seemed to be responsible for the activation of toxin genes. The virX knock out mutant of wild-type strain 13 showed a reduced expression of the plc, colA, and pfoA genes, which was complemented by the transformation of the intact virX gene. Deletion and site-directed mutagenesis studies suggested that the virX gene acts as a regulatory RNA rather than as a peptide regulator. The virX locus found in this study might play a part in the signal transduction to regulate toxin production in C. perfringens." @default.
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- W2041195700 date "2002-03-01" @default.
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- W2041195700 title "Identification of a novel locus that regulates expression of toxin genes in<i>Clostridium perfringens</i>" @default.
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- W2041195700 doi "https://doi.org/10.1111/j.1574-6968.2002.tb11118.x" @default.
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