FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041199367> ?p ?o ?g. }

• W2041199367 endingPage "11121" @default.
• W2041199367 startingPage "1115" @default.
• W2041199367 abstract "Therapeutic intervention with antiretroviral therapy (ART) enables the modulation of HIV virus load and hence provides a unique opportunity to study the consequences of varying antigen load on the phenotype of virus-specific CD8(+) T lymphocytes in a persistent human viral infection. The recent advent of tetrameric peptide / HLA class I complexes has enabled the direct phenotypic characterization of antigen-specific T cell populations ex vivo. Here, we use this technology to examine directly ex vivo the consequences of therapeutic manipulation of HIV virus load on the phenotype of HIV-specific CTL. Our observations show that: (1) distinct sequential activation patterns of CD8(+) T cells are associated with increasing virus load; (2) T cell receptor (TCR) down-regulation without apoptosis represents an early event during the generation of a T cell response in a natural infection and precedes the emergence of two distinct antigen-specific CD8(+) T cell populations which differ in TCR and CD8 expression levels. Clear differences in surface Annexin V staining were observed between these populations. The observation that CTL activation, demonstrated by TCR and CD8 down-regulation, in response to rising levels of virus load, co-segregates with apoptosis only during later stages of the response indicates that antigen-associated cell death is restricted to distinct subpopulations of CTL." @default.
• W2041199367 created "2016-06-24" @default.
• W2041199367 creator A5001255253 @default.
• W2041199367 creator A5008537578 @default.
• W2041199367 creator A5046316209 @default.
• W2041199367 creator A5051791661 @default.
• W2041199367 creator A5058664398 @default.
• W2041199367 creator A5060213700 @default.
• W2041199367 creator A5063476882 @default.
• W2041199367 creator A5067056877 @default.
• W2041199367 creator A5088187599 @default.
• W2041199367 date "2001-04-01" @default.
• W2041199367 modified "2023-09-23" @default.
• W2041199367 title "Directex vivo analysis reveals distinct phenotypic patterns of HIV-specific CD8+ T lymphocyte activation in response to therapeutic manipulation of virus load" @default.
• W2041199367 cites W1519418301 @default.
• W2041199367 cites W1612956065 @default.
• W2041199367 cites W1780524789 @default.
• W2041199367 cites W1988857387 @default.
• W2041199367 cites W1998415250 @default.
• W2041199367 cites W1998690402 @default.
• W2041199367 cites W2010064858 @default.
• W2041199367 cites W2011037737 @default.
• W2041199367 cites W2018570381 @default.
• W2041199367 cites W2023809975 @default.
• W2041199367 cites W2025465431 @default.
• W2041199367 cites W2025783409 @default.
• W2041199367 cites W2026615262 @default.
• W2041199367 cites W2046279172 @default.
• W2041199367 cites W2058001723 @default.
• W2041199367 cites W2067069532 @default.
• W2041199367 cites W2069340283 @default.
• W2041199367 cites W2081200884 @default.
• W2041199367 cites W2084195248 @default.
• W2041199367 cites W2089378524 @default.
• W2041199367 cites W2095520403 @default.
• W2041199367 cites W2109372137 @default.
• W2041199367 cites W2115973917 @default.
• W2041199367 cites W2117003890 @default.
• W2041199367 cites W2119232577 @default.
• W2041199367 cites W2123575047 @default.
• W2041199367 cites W2137478600 @default.
• W2041199367 cites W2139229993 @default.
• W2041199367 cites W2152441029 @default.
• W2041199367 cites W2159531745 @default.
• W2041199367 cites W2168905701 @default.
• W2041199367 doi "https://doi.org/10.1002/1521-4141(200104)31:4<1115::aid-immu1115>3.0.co;2-9" @default.
• W2041199367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11298336" @default.
• W2041199367 hasPublicationYear "2001" @default.
• W2041199367 type Work @default.
• W2041199367 sameAs 2041199367 @default.
• W2041199367 citedByCount "25" @default.
• W2041199367 countsByYear W20411993672012 @default.
• W2041199367 countsByYear W20411993672013 @default.
• W2041199367 countsByYear W20411993672015 @default.
• W2041199367 crossrefType "journal-article" @default.
• W2041199367 hasAuthorship W2041199367A5001255253 @default.
• W2041199367 hasAuthorship W2041199367A5008537578 @default.
• W2041199367 hasAuthorship W2041199367A5046316209 @default.
• W2041199367 hasAuthorship W2041199367A5051791661 @default.
• W2041199367 hasAuthorship W2041199367A5058664398 @default.
• W2041199367 hasAuthorship W2041199367A5060213700 @default.
• W2041199367 hasAuthorship W2041199367A5063476882 @default.
• W2041199367 hasAuthorship W2041199367A5067056877 @default.
• W2041199367 hasAuthorship W2041199367A5088187599 @default.
• W2041199367 hasBestOaLocation W20411993671 @default.
• W2041199367 hasConcept C104317684 @default.
• W2041199367 hasConcept C127716648 @default.
• W2041199367 hasConcept C142462285 @default.
• W2041199367 hasConcept C147483822 @default.
• W2041199367 hasConcept C147969180 @default.
• W2041199367 hasConcept C154317977 @default.
• W2041199367 hasConcept C159047783 @default.
• W2041199367 hasConcept C167672396 @default.
• W2041199367 hasConcept C19317047 @default.
• W2041199367 hasConcept C202751555 @default.
• W2041199367 hasConcept C203014093 @default.
• W2041199367 hasConcept C207001950 @default.
• W2041199367 hasConcept C2522874641 @default.
• W2041199367 hasConcept C26291073 @default.
• W2041199367 hasConcept C2776090121 @default.
• W2041199367 hasConcept C54355233 @default.
• W2041199367 hasConcept C86803240 @default.
• W2041199367 hasConcept C8891405 @default.
• W2041199367 hasConcept C95444343 @default.
• W2041199367 hasConceptScore W2041199367C104317684 @default.
• W2041199367 hasConceptScore W2041199367C127716648 @default.
• W2041199367 hasConceptScore W2041199367C142462285 @default.
• W2041199367 hasConceptScore W2041199367C147483822 @default.
• W2041199367 hasConceptScore W2041199367C147969180 @default.
• W2041199367 hasConceptScore W2041199367C154317977 @default.
• W2041199367 hasConceptScore W2041199367C159047783 @default.
• W2041199367 hasConceptScore W2041199367C167672396 @default.
• W2041199367 hasConceptScore W2041199367C19317047 @default.
• W2041199367 hasConceptScore W2041199367C202751555 @default.
• W2041199367 hasConceptScore W2041199367C203014093 @default.
• W2041199367 hasConceptScore W2041199367C207001950 @default.
• W2041199367 hasConceptScore W2041199367C2522874641 @default.
• W2041199367 hasConceptScore W2041199367C26291073 @default.

• next