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- W2041220005 abstract "T-cell growth factor, a mitogenic protein released from lectin- or antigen-activated mononuclear cells, maintains T-lymphocytes in continuous exponential proliferative culture. Studies which explored the parameters required for TCGF production revealed that both mature thymic-dependent T-cells and adherent cells participated in the release of TCGF. Further experimentation suggested that T-cells released TCGF after receiving two signals; (1) lectin or antigen cell membrane binding, and (2) a soluble product derived from adherent cells. A separate subset of T-cells, which did not require thymic influence, responded to TCGF. TCGF appeared to interact with the TCGF-responsive subset via specific membrane receptors: TCGF could be absorbed only by lectin- or antigen-activated living or glutaraldehyde-fixed T-cells. The T-cell response was initiated by lectin or antigen, but proliferation was mediated solely by purified TCGF. Thus, the T-cell immune response, which culminates in clonal expansion and differentiation of antigenreactive cells, appears to be controlled by an endogenously-derived proliferative hormone, which is obligatory for the realization of a competent effector T-cell." @default.
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- W2041220005 date "1980-05-01" @default.
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- W2041220005 title "Functional and molecular characteristics of t-cell growth factor" @default.
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- W2041220005 doi "https://doi.org/10.1016/0161-5890(80)90156-x" @default.
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