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- W2041226615 endingPage "114" @default.
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- W2041226615 abstract "Our laboratory investigates systemic autoimmune disease in the context of mouse models of systemic lupus erythematosus (SLE). SLE is associated with high titers of serum autoantibodies of the IgG class that are predominantly directed against nuclear antigens, with pathological manifestations that are considered by many to be characteristic of an immune-complex mediated disease. In this review, we focus on the known and potential roles of somatic mutagenesis in SLE. We will argue that anti-nuclear antibodies (ANA) arise predominantly from nonautoreactive B cells that are transformed into autoreactive cells by the process of somatic hypermutation (SHM), which is normally associated with affinity maturation during the germinal center reaction. We will also discuss the role of SHM in creating antigenic peptides in the V region of the B cell receptor (BCR) and its potential to open an avenue of unregulated T cell help to autoreactive B cells. Finally, we will end this review with new experimental evidence suggesting that spontaneous somatic mutagenesis of genes that regulate B cell survival and activation is a rate-limiting causative factor in the development of ANA." @default.
- W2041226615 created "2016-06-24" @default.
- W2041226615 creator A5000854416 @default.
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- W2041226615 creator A5027692912 @default.
- W2041226615 creator A5046732953 @default.
- W2041226615 creator A5072964153 @default.
- W2041226615 date "2013-01-18" @default.
- W2041226615 modified "2023-09-25" @default.
- W2041226615 title "Somatic mutagenesis in autoimmunity" @default.
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