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- W2041246499 abstract "Abstract Clinical and biochemical studies in a patient with metastatic gastric carcinoid are presented. The findings of this patient and in three similar patients described previously seem to justify consideration of a unique syndrome, consisting of distinctive flushes, persistently elevated urinary histamine and secretion of 5-hydroxytryptophan (5HTP) by carcinoid tumors of gastric origin. Elaboration of 5HTP, rather than serotonin, by the tumor is reflected in normal platelet serotonin values, and urinary excretion of 5HTP, serotonin and 5-hydroxyindoleacetic acid in proportions almost identical with those found following infusion of 5HTP in control subjects. The excretion of 5-hydroxyindoles and histamine in our patient with gastric carcinoid is compared with that in thirteen patients with carcinoid tumors from non-gastric or unknown primary sites. That the rate of tryptophan hydroxylation can be increased by raising substrate concentration is shown by the elevations in urinary 5HTP following oral administration of l-tryptophan in this patient. Evidence is presented that the increased excretion of histamine is not related to elevated tissue concentrations of 5HTP or serotonin. Thus treatment with the aromatic l-amino acid decarboxylase inhibitor, α-methyl-dopa, reduced 5HTP decarboxylation but failed to alter the urinary excretion of histamine. The clinical response to α-methyl-dopa therapy in the patient with gastric carcinoid was better than has been obtained in patients with the usual type of carcinoid syndrome. A possible explanation for this is offered and the importance of recognizing this variant syndrome is emphasized." @default.
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- W2041246499 title "A unique syndrome associated with secretion of 5-hydroxytryptophan by metastatic gastric carcinoids" @default.
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- W2041246499 doi "https://doi.org/10.1016/0002-9343(62)90124-9" @default.
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