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- W2041253025 abstract "Whether volatile anesthetics have an effect on the peripheral chemoreceptors is controversial, possibly because of differences in end-tidal CO2 concentrations. We studied the effect of isoflurane on the hypoxic chemosensitivity of carotid body chemoreceptors at three different Paco2 levels before and during the administration of 1.0% isoflurane (0.5 minimum alveolar anesthetic concentration) in six normothermic New Zealand white rabbits anesthetized with thiopental. The response of the chemoreceptors was fitted to the equation:Frequency (Hz) = a + b ×Paco2+ c ×(1/Pao2) + d ×(1/Pao2)2. Mean values for the coefficients a, b, c and d for the control state were −4.5, 0.13, 771, and 6332, respectively. This relationship was not changed by addition of isoflurane at 1.0% end-tidal concentration (P = 0.40, analysis of variance). We conclude that isoflurane at 1.0% end-tidal concentration does not depress the hypoxic response of rabbit carotid body chemoreceptors during either hypo-, normo-, or hypercapnia. Implications By measuring single-fiber chemoreceptor activity in anesthetized rabbits, we showed that isoflurane at 1.0% end-tidal concentration does not depress the hypoxic chemosensitivity of peripheral chemoreceptors during either hypo-, normo-, or hypercapnia in this species." @default.
- W2041253025 created "2016-06-24" @default.
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- W2041253025 date "2000-08-01" @default.
- W2041253025 modified "2023-09-27" @default.
- W2041253025 title "Isoflurane Does Not Depress the Hypoxic Response of Rabbit Carotid Body Chemoreceptors" @default.
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- W2041253025 doi "https://doi.org/10.1097/00000539-200008000-00047" @default.
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