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- W2041255038 abstract "In response to Isbister et al, 1 Isbister G.K. Page C.B. Buckley N.A. et al. Randomized controlled trial of intravenous antivenom versus placebo for latrodectism: the second Redback Antivenom Evaluation (RAVE-II) study. Ann Emerg Med. 2014; 64: 620-628 Abstract Full Text Full Text PDF PubMed Scopus (32) Google Scholar envenoming by widow spiders (Latrodectus; latrodectism) arguably represents the single most medically important global subset of spider bites. In patients with significant envenoming, death is a rare outcome, but marked and distressing discomfort is typical. 2 White J. Clinical toxicology of spider bite. in: Meier J. White J. Handbook of Clinical Toxicology of Animal Venoms and Poisons. CRC Press, Boca Raton, FL1995: 259-329 Google Scholar This may last only several hours but often persists for greater than 24 hours, up to several days or even weeks. Providing effective treatment to reduce both the level and period of distress is the therapeutic goal. Randomized Controlled Trial of Intravenous Antivenom Versus Placebo for Latrodectism: The Second Redback Antivenom Evaluation (RAVE-II) StudyAnnals of Emergency MedicineVol. 64Issue 6PreviewLatrodectism is the most important spider envenomation syndrome worldwide. There remains considerable controversy over antivenom treatment. We aimed to investigate whether antivenom resulted in resolution of pain and systemic effects in patients with latrodectism who received standardized analgesia. Full-Text PDF In replyAnnals of Emergency MedicineVol. 65Issue 1PreviewWe agree with White and Weinstein that our placebo randomized controlled trial,1 to our knowledge the largest ever conducted for this condition, is at odds with past recommendations and their anecdotal experience. However, there are numerous examples in the medical literature of new evidence of lack of effectiveness leading to abandonment of established medical treatments.2 Even when the previous evidence is poor, such as with latrodectism, many physicians will find it difficult to abandon long-established practices and will advocate reasons not to change. Full-Text PDF" @default.
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- W2041255038 title "Latrodectism and Effectiveness of Antivenom" @default.
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- W2041255038 doi "https://doi.org/10.1016/j.annemergmed.2014.08.022" @default.
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