Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041262721> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2041262721 endingPage "378" @default.
- W2041262721 startingPage "371" @default.
- W2041262721 abstract "Transduction mechanisms associated with ligand binding at diazepam-insensitive subtypes of GABAA receptors remain largely unknown, but unique behavioral effects of ligands binding at these sites have been reported in pigeons. The present study further evaluated the pharmacological characteristics of diazepam-insensitive GABAA receptors in pigeon brain, using [3H]Ro 15-4513. Autoradiography detected diazepam-insensitive benzodiazepine sites on GABAA receptors in a number of brain regions, with the highest densities present in the olfactory bulb, hippocampus, thalamic nuclei and cerebellar granule cell layers, with densities of approximately 10-20% of total benzodiazepine receptor binding. Saturation analysis revealed significant densities (approximately 10% of total benzodiazepine receptor binding) of extracerebellar diazepam-insensitive benzodiazepine receptors in optic lobe, hippocampus, and brainstem compared to 27% in cerebellum. As reported for mammalian diazepam-sensitive benzodiazepine receptors, GABA (50 microM) generally increased the affinities of agonists and partial agonists, had little effect on the affinities of antagonists, and decreased the affinity of an inverse agonist for pigeon cerebellar diazepam-sensitive benzodiazepine receptors. GABA modulation of ligand binding to diazepam-insensitive benzodiazepine receptors was less than that observed for diazepam-sensitive sites, and no positive modulation was observed. These results demonstrate the presence of cerebellar and extracerebellar diazepam-insensitive benzodiazepine receptors in pigeon brain, with distribution patterns and pharmacology similar to those reported in mammals. The comparable central localization and pharmacological properties of drugs at diazepam-sensitive and -insensitive benzodiazepine receptors in pigeons and rats attests to the evolutionary conservation of GABAA systems." @default.
- W2041262721 created "2016-06-24" @default.
- W2041262721 creator A5040741799 @default.
- W2041262721 creator A5045732236 @default.
- W2041262721 creator A5063000955 @default.
- W2041262721 creator A5090899159 @default.
- W2041262721 creator A5054400712 @default.
- W2041262721 date "1997-02-01" @default.
- W2041262721 modified "2023-09-27" @default.
- W2041262721 title "Localization and pharmacological characterization of pigeon diazepam-insensitive GABAA receptors" @default.
- W2041262721 cites W1524203275 @default.
- W2041262721 cites W1846228594 @default.
- W2041262721 cites W1916068919 @default.
- W2041262721 cites W1989267322 @default.
- W2041262721 cites W1990754268 @default.
- W2041262721 cites W1994785056 @default.
- W2041262721 cites W1994831700 @default.
- W2041262721 cites W2009358137 @default.
- W2041262721 cites W2018256218 @default.
- W2041262721 cites W2020285615 @default.
- W2041262721 cites W2023752814 @default.
- W2041262721 cites W2024488069 @default.
- W2041262721 cites W2024545561 @default.
- W2041262721 cites W2026920124 @default.
- W2041262721 cites W2029227717 @default.
- W2041262721 cites W2030687516 @default.
- W2041262721 cites W2042333279 @default.
- W2041262721 cites W2042443893 @default.
- W2041262721 cites W2044662388 @default.
- W2041262721 cites W2057415531 @default.
- W2041262721 cites W2060586131 @default.
- W2041262721 cites W2075723143 @default.
- W2041262721 cites W2082128892 @default.
- W2041262721 cites W2091496385 @default.
- W2041262721 cites W2145845873 @default.
- W2041262721 cites W2164870491 @default.
- W2041262721 cites W2198832395 @default.
- W2041262721 cites W2253482024 @default.
- W2041262721 cites W2493705182 @default.
- W2041262721 cites W2973016784 @default.
- W2041262721 doi "https://doi.org/10.1016/s0306-4522(96)00469-1" @default.
- W2041262721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9472397" @default.
- W2041262721 hasPublicationYear "1997" @default.
- W2041262721 type Work @default.
- W2041262721 sameAs 2041262721 @default.
- W2041262721 citedByCount "5" @default.
- W2041262721 crossrefType "journal-article" @default.
- W2041262721 hasAuthorship W2041262721A5040741799 @default.
- W2041262721 hasAuthorship W2041262721A5045732236 @default.
- W2041262721 hasAuthorship W2041262721A5054400712 @default.
- W2041262721 hasAuthorship W2041262721A5063000955 @default.
- W2041262721 hasAuthorship W2041262721A5090899159 @default.
- W2041262721 hasConcept C134018914 @default.
- W2041262721 hasConcept C168258287 @default.
- W2041262721 hasConcept C170493617 @default.
- W2041262721 hasConcept C185592680 @default.
- W2041262721 hasConcept C2776175493 @default.
- W2041262721 hasConcept C2778173252 @default.
- W2041262721 hasConcept C2778409475 @default.
- W2041262721 hasConcept C2778938600 @default.
- W2041262721 hasConcept C2779652256 @default.
- W2041262721 hasConcept C55493867 @default.
- W2041262721 hasConcept C86803240 @default.
- W2041262721 hasConcept C89951826 @default.
- W2041262721 hasConcept C98274493 @default.
- W2041262721 hasConceptScore W2041262721C134018914 @default.
- W2041262721 hasConceptScore W2041262721C168258287 @default.
- W2041262721 hasConceptScore W2041262721C170493617 @default.
- W2041262721 hasConceptScore W2041262721C185592680 @default.
- W2041262721 hasConceptScore W2041262721C2776175493 @default.
- W2041262721 hasConceptScore W2041262721C2778173252 @default.
- W2041262721 hasConceptScore W2041262721C2778409475 @default.
- W2041262721 hasConceptScore W2041262721C2778938600 @default.
- W2041262721 hasConceptScore W2041262721C2779652256 @default.
- W2041262721 hasConceptScore W2041262721C55493867 @default.
- W2041262721 hasConceptScore W2041262721C86803240 @default.
- W2041262721 hasConceptScore W2041262721C89951826 @default.
- W2041262721 hasConceptScore W2041262721C98274493 @default.
- W2041262721 hasIssue "2" @default.
- W2041262721 hasLocation W20412627211 @default.
- W2041262721 hasLocation W20412627212 @default.
- W2041262721 hasOpenAccess W2041262721 @default.
- W2041262721 hasPrimaryLocation W20412627211 @default.
- W2041262721 hasRelatedWork W1886221373 @default.
- W2041262721 hasRelatedWork W1990402164 @default.
- W2041262721 hasRelatedWork W1990625391 @default.
- W2041262721 hasRelatedWork W1992475965 @default.
- W2041262721 hasRelatedWork W1994700139 @default.
- W2041262721 hasRelatedWork W2015592783 @default.
- W2041262721 hasRelatedWork W2019163974 @default.
- W2041262721 hasRelatedWork W2046660718 @default.
- W2041262721 hasRelatedWork W2061945417 @default.
- W2041262721 hasRelatedWork W2086909289 @default.
- W2041262721 hasVolume "77" @default.
- W2041262721 isParatext "false" @default.
- W2041262721 isRetracted "false" @default.
- W2041262721 magId "2041262721" @default.
- W2041262721 workType "article" @default.