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• W2041266518 abstract "Abstract Purpose To investigate the MRI characteristics of an intracellular manganese‐based contrast agent, EVP 1001‐1 (Eagle Vision Pharmaceutical Corp.), in a canine model of myocardial infarction. Materials and Methods Three dogs were imaged 14–37 days following permanent ligation of the left anterior descending coronary artery (LAD). Measurements of the longitudinal relaxation rate R 1 were made prior to EVP 1001‐1 administration (20 μmol/kg i.v.) and for one hour thereafter. Triphenyl tetrazolium chloride (TTC) staining was used to document infarction. Results In normal myocardium, EVP 1001‐1 produced a substantial increase in the longitudinal relaxation rate, which remained fairly constant over the postcontrast imaging period (ΔR 1 = 1.47 ± 0.58 sec −1 (mean ± SD) at 35 minutes, P < 0.05). In the infarct, the response to EVP 1001‐1 was small or negligible (ΔR 1 = 0.27 ± 0.28 sec −1 ). This resulted in a significant postcontrast difference in relaxation rate between normal and infarcted tissue (R 1 (normal) − R 1 (infarct) = 1.08 ± 0.26 sec −1 , P < 0.05). The infarct remained clearly delineated in all animals throughout the steady‐state imaging period, and qualitatively matched TTC results. Conclusion The persistent enhancement pattern revealed by MRI following EVP 1001‐1 administration may be beneficial for identifying and characterizing myocardial infarction. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc." @default.
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• W2041266518 date "2006-01-13" @default.
• W2041266518 modified "2023-10-13" @default.
• W2041266518 title "Magnetic resonance imaging of myocardial infarction using a manganese-based contrast agent (EVP 1001-1): Preliminary results in a Dog model" @default.
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• W2041266518 doi "https://doi.org/10.1002/jmri.20500" @default.
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