FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041277487> ?p ?o ?g. }

• W2041277487 endingPage "371" @default.
• W2041277487 startingPage "361" @default.
• W2041277487 abstract "Hormonal imbalances are involved in many of the age-related pathologies, as neurodegenerative and psychiatric diseases. Specifically, thyroid state alterations in the adult are related to psychological changes and mood disorders as depression. The dentate gyrus of the hippocampal formation undergoes neurogenesis in adult mammals including humans. Recent evidence suggests that depressive disorders and their treatment are tightly related to the number of newly born neurons in the dentate gyrus. We have studied the effect of thyroid hormones (TH) on hippocampal neurogenesis in adult rats in vivo. A short period of adult-onset hypothyroidism impaired normal neurogenesis in the subgranular zone of the dentate gyrus with a 30% reduction in the number of proliferating cells. Hypothyroidism also reduced the number of newborn neuroblasts and immature neurons (doublecortin (DCX) immunopositive cells) which had a severely hypoplastic dendritic arborization. To correlate these changes with hippocampal function, we subjected the rats to the forced swimming and novel object recognition tests. Hypothyroid rats showed normal memory in object recognition, but displayed abnormal behavior in the forced swimming test, indicating a depressive-like disorder. Chronic treatment of hypothyroid rats with TH not only normalized the abnormal behavior but also restored the number of proliferative and DCX-positive cells, and induced growth of their dendritic trees. Therefore, hypothyroidism induced a reversible depressive-like disorder, which correlated to changes in neurogenesis. Our results indicate that TH are essential for adult hippocampal neurogenesis and suggest that mood disorders related to adult-onset hypothyroidism in humans could be due, in part, to impaired neurogenesis." @default.
• W2041277487 created "2016-06-24" @default.
• W2041277487 creator A5015217389 @default.
• W2041277487 creator A5018809456 @default.
• W2041277487 creator A5030065228 @default.
• W2041277487 creator A5035095061 @default.
• W2041277487 creator A5037234666 @default.
• W2041277487 creator A5041622914 @default.
• W2041277487 creator A5042689915 @default.
• W2041277487 date "2006-01-31" @default.
• W2041277487 modified "2023-10-18" @default.
• W2041277487 title "Modulation of adult hippocampal neurogenesis by thyroid hormones: implications in depressive-like behavior" @default.
• W2041277487 cites W1487852103 @default.
• W2041277487 cites W1581458838 @default.
• W2041277487 cites W1631784856 @default.
• W2041277487 cites W1764972970 @default.
• W2041277487 cites W1775250759 @default.
• W2041277487 cites W1865353504 @default.
• W2041277487 cites W1897711211 @default.
• W2041277487 cites W1963940970 @default.
• W2041277487 cites W1968761011 @default.
• W2041277487 cites W1969014948 @default.
• W2041277487 cites W1972421000 @default.
• W2041277487 cites W1977456440 @default.
• W2041277487 cites W1981007591 @default.
• W2041277487 cites W1983592226 @default.
• W2041277487 cites W1986346910 @default.
• W2041277487 cites W1988222321 @default.
• W2041277487 cites W1996855228 @default.
• W2041277487 cites W1996907803 @default.
• W2041277487 cites W2002363989 @default.
• W2041277487 cites W2012173637 @default.
• W2041277487 cites W2021314292 @default.
• W2041277487 cites W2024292910 @default.
• W2041277487 cites W2025604203 @default.
• W2041277487 cites W2048465410 @default.
• W2041277487 cites W2050073835 @default.
• W2041277487 cites W2051021067 @default.
• W2041277487 cites W2053032855 @default.
• W2041277487 cites W2055394344 @default.
• W2041277487 cites W2055561480 @default.
• W2041277487 cites W2057821382 @default.
• W2041277487 cites W2060175921 @default.
• W2041277487 cites W2062684307 @default.
• W2041277487 cites W2063075351 @default.
• W2041277487 cites W2063739205 @default.
• W2041277487 cites W2064994363 @default.
• W2041277487 cites W2067797384 @default.
• W2041277487 cites W2067856703 @default.
• W2041277487 cites W2068672685 @default.
• W2041277487 cites W2072441360 @default.
• W2041277487 cites W2074764259 @default.
• W2041277487 cites W2083434988 @default.
• W2041277487 cites W2089299823 @default.
• W2041277487 cites W2090755454 @default.
• W2041277487 cites W2091221706 @default.
• W2041277487 cites W2093541378 @default.
• W2041277487 cites W2096582296 @default.
• W2041277487 cites W2097448914 @default.
• W2041277487 cites W2106411599 @default.
• W2041277487 cites W2116961945 @default.
• W2041277487 cites W2130124581 @default.
• W2041277487 cites W2133565799 @default.
• W2041277487 cites W2136855986 @default.
• W2041277487 cites W2138135102 @default.
• W2041277487 cites W2139481908 @default.
• W2041277487 cites W2140129376 @default.
• W2041277487 cites W2140783655 @default.
• W2041277487 cites W2143337494 @default.
• W2041277487 cites W2145235967 @default.
• W2041277487 cites W2148239264 @default.
• W2041277487 cites W2152820394 @default.
• W2041277487 cites W2153533547 @default.
• W2041277487 cites W2154152289 @default.
• W2041277487 cites W2155835215 @default.
• W2041277487 cites W2159946264 @default.
• W2041277487 cites W2165022229 @default.
• W2041277487 cites W2586601476 @default.
• W2041277487 cites W4240768753 @default.
• W2041277487 cites W893501938 @default.
• W2041277487 doi "https://doi.org/10.1038/sj.mp.4001802" @default.
• W2041277487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16446739" @default.
• W2041277487 hasPublicationYear "2006" @default.
• W2041277487 type Work @default.
• W2041277487 sameAs 2041277487 @default.
• W2041277487 citedByCount "141" @default.
• W2041277487 countsByYear W20412774872012 @default.
• W2041277487 countsByYear W20412774872013 @default.
• W2041277487 countsByYear W20412774872014 @default.
• W2041277487 countsByYear W20412774872015 @default.
• W2041277487 countsByYear W20412774872016 @default.
• W2041277487 countsByYear W20412774872017 @default.
• W2041277487 countsByYear W20412774872018 @default.
• W2041277487 countsByYear W20412774872019 @default.
• W2041277487 countsByYear W20412774872020 @default.
• W2041277487 countsByYear W20412774872021 @default.
• W2041277487 countsByYear W20412774872022 @default.
• W2041277487 countsByYear W20412774872023 @default.

• next