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• W2041285227 abstract "RNA helicase A (RHA), a DExD/H protein, contains a stretch of repeated arginine and glycine-glycine (RGG) residues and an oligonucleotide/oligosaccharide-binding fold (OB-fold) at the C-terminus. RHA has been reported to function as a transcriptional cofactor. This study shows the role of RGG and OB-fold domains of RHA in the activation of transcription and splicing of HIV-1 RNA. RHA stimulates HIV-1 transcription by enhancing the occupancy of RNA polymerase II on the proviral DNA. Deletion of RGG or both RGG and OB-fold does not change the transcriptional activity of RHA, nor does the stability of viral RNA. However, deletion of both RGG and OB-fold rather than deletion of RGG only results in less production of multiply spliced 6D RNAs. The results suggest that the OB-fold is involved in modulating HIV-1 RNA splicing in the context of some HIV-1 strains while it is dispensable for the activation of HIV-1 transcription." @default.
• W2041285227 created "2016-06-24" @default.
• W2041285227 creator A5008995173 @default.
• W2041285227 creator A5030529590 @default.
• W2041285227 creator A5069490653 @default.
• W2041285227 date "2014-11-01" @default.
• W2041285227 modified "2023-09-26" @default.
• W2041285227 title "Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA" @default.
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• W2041285227 doi "https://doi.org/10.1016/j.bbagrm.2014.08.008" @default.
• W2041285227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25149208" @default.
• W2041285227 hasPublicationYear "2014" @default.
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