FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041293328> ?p ?o ?g. }

• W2041293328 endingPage "510" @default.
• W2041293328 startingPage "505" @default.
• W2041293328 abstract "Proteins interacting with the human PDGF (platelet-derived growth factor) beta-receptor were isolated using immobilized peptides derived from the receptor C-terminus as a bait. We identified two PDZ domain proteins, namely NHERF (Na(+)/H(+) exchanger regulatory factor, also called EBP50) and NHERF2 (E3KARP, SIP-1, TKA-1), which have been shown previously to associate with the murine PDGF receptor [Maudsley, Zamah, Rahman, Blitzer, Luttrell, Lefkowitz and Hall (2000) Mol. Cell. Biol. 20, 8352-8363]. In porcine aortic endothelial cells and in fibroblasts, NHERF recruitment was induced by PDGF treatment, but the receptor kinase activity was not required for the formation of the complex, suggesting that NHERF was not recruited in a phosphotyrosine-dependent manner. Instead, the interaction was abolished by mutation of the consensus C-terminal PDZ-interacting domain of the receptor (Leu-1106 to Ala), or truncation of the last 75 amino acid residues of the receptor. Disruption of NHERF binding to the receptor enhanced actin filament reorganization, but did not affect PDGF-induced mitogenicity and chemotaxis. Although NHERF was initially characterized as a factor required for intracellular pH regulation by beta2-adrenergic receptors, we observed that it was not involved in pH regulation by PDGF. Collectively, these results suggest that the ligand-induced association of NHERF PDZ domain with the PDGF receptor tyrosine kinase controls the extent of cytoskeleton reorganization in response to PDGF." @default.
• W2041293328 created "2016-06-24" @default.
• W2041293328 creator A5000360108 @default.
• W2041293328 creator A5018148458 @default.
• W2041293328 creator A5032534504 @default.
• W2041293328 creator A5053119654 @default.
• W2041293328 creator A5068300247 @default.
• W2041293328 creator A5083737061 @default.
• W2041293328 creator A5084535456 @default.
• W2041293328 date "2003-12-01" @default.
• W2041293328 modified "2023-10-17" @default.
• W2041293328 title "Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF" @default.
• W2041293328 cites W1483932465 @default.
• W2041293328 cites W1507084693 @default.
• W2041293328 cites W1828225209 @default.
• W2041293328 cites W1966704740 @default.
• W2041293328 cites W1984104020 @default.
• W2041293328 cites W1988318644 @default.
• W2041293328 cites W1990787112 @default.
• W2041293328 cites W1996836065 @default.
• W2041293328 cites W2009458860 @default.
• W2041293328 cites W2012460154 @default.
• W2041293328 cites W2012819315 @default.
• W2041293328 cites W2022125301 @default.
• W2041293328 cites W2029583949 @default.
• W2041293328 cites W2047485981 @default.
• W2041293328 cites W2062241862 @default.
• W2041293328 cites W2067369435 @default.
• W2041293328 cites W2074644169 @default.
• W2041293328 cites W2097146615 @default.
• W2041293328 cites W2110121929 @default.
• W2041293328 cites W2136205584 @default.
• W2041293328 cites W2141240174 @default.
• W2041293328 cites W2147469756 @default.
• W2041293328 cites W2149442576 @default.
• W2041293328 cites W2183657089 @default.
• W2041293328 cites W2338100394 @default.
• W2041293328 doi "https://doi.org/10.1042/bj20030385" @default.
• W2041293328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1223789" @default.
• W2041293328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12967325" @default.
• W2041293328 hasPublicationYear "2003" @default.
• W2041293328 type Work @default.
• W2041293328 sameAs 2041293328 @default.
• W2041293328 citedByCount "47" @default.
• W2041293328 countsByYear W20412933282012 @default.
• W2041293328 countsByYear W20412933282013 @default.
• W2041293328 countsByYear W20412933282014 @default.
• W2041293328 countsByYear W20412933282015 @default.
• W2041293328 countsByYear W20412933282017 @default.
• W2041293328 countsByYear W20412933282018 @default.
• W2041293328 crossrefType "journal-article" @default.
• W2041293328 hasAuthorship W2041293328A5000360108 @default.
• W2041293328 hasAuthorship W2041293328A5018148458 @default.
• W2041293328 hasAuthorship W2041293328A5032534504 @default.
• W2041293328 hasAuthorship W2041293328A5053119654 @default.
• W2041293328 hasAuthorship W2041293328A5068300247 @default.
• W2041293328 hasAuthorship W2041293328A5083737061 @default.
• W2041293328 hasAuthorship W2041293328A5084535456 @default.
• W2041293328 hasBestOaLocation W20412933282 @default.
• W2041293328 hasConcept C101544691 @default.
• W2041293328 hasConcept C142669718 @default.
• W2041293328 hasConcept C1491633281 @default.
• W2041293328 hasConcept C154428179 @default.
• W2041293328 hasConcept C170493617 @default.
• W2041293328 hasConcept C180361614 @default.
• W2041293328 hasConcept C185592680 @default.
• W2041293328 hasConcept C2775960820 @default.
• W2041293328 hasConcept C2781294074 @default.
• W2041293328 hasConcept C2993400109 @default.
• W2041293328 hasConcept C49658373 @default.
• W2041293328 hasConcept C55493867 @default.
• W2041293328 hasConcept C62478195 @default.
• W2041293328 hasConcept C86803240 @default.
• W2041293328 hasConcept C95444343 @default.
• W2041293328 hasConceptScore W2041293328C101544691 @default.
• W2041293328 hasConceptScore W2041293328C142669718 @default.
• W2041293328 hasConceptScore W2041293328C1491633281 @default.
• W2041293328 hasConceptScore W2041293328C154428179 @default.
• W2041293328 hasConceptScore W2041293328C170493617 @default.
• W2041293328 hasConceptScore W2041293328C180361614 @default.
• W2041293328 hasConceptScore W2041293328C185592680 @default.
• W2041293328 hasConceptScore W2041293328C2775960820 @default.
• W2041293328 hasConceptScore W2041293328C2781294074 @default.
• W2041293328 hasConceptScore W2041293328C2993400109 @default.
• W2041293328 hasConceptScore W2041293328C49658373 @default.
• W2041293328 hasConceptScore W2041293328C55493867 @default.
• W2041293328 hasConceptScore W2041293328C62478195 @default.
• W2041293328 hasConceptScore W2041293328C86803240 @default.
• W2041293328 hasConceptScore W2041293328C95444343 @default.
• W2041293328 hasIssue "2" @default.
• W2041293328 hasLocation W20412933281 @default.
• W2041293328 hasLocation W20412933282 @default.
• W2041293328 hasLocation W20412933283 @default.
• W2041293328 hasLocation W20412933284 @default.
• W2041293328 hasLocation W20412933285 @default.
• W2041293328 hasLocation W20412933286 @default.
• W2041293328 hasOpenAccess W2041293328 @default.
• W2041293328 hasPrimaryLocation W20412933281 @default.

• next