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- W2041304204 abstract "Sustained stimulation of sensory organs results in adaptation of the neuronal response along the sensory pathway. Whether or not cortical adaptation affects equally excitation and inhibition is poorly understood. We examined this question using patch recordings of neurons in the barrel cortex of anesthetized rats while repetitively stimulating the principal whisker. We found that inhibition adapts more than excitation, causing the balance between them to shift toward excitation. A comparison of the latency of thalamic firing and evoked excitation and inhibition in the cortex strongly suggests that adaptation of inhibition results mostly from depression of inhibitory synapses rather than adaptation in the firing of inhibitory cells. The differential adaptation of the evoked conductances that shifts the balance toward excitation may act as a gain mechanism which enhances the subthreshold response during sustained stimulation, despite a large reduction in excitation." @default.
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- W2041304204 date "2008-12-03" @default.
- W2041304204 modified "2023-10-11" @default.
- W2041304204 title "Shift in the Balance between Excitation and Inhibition during Sensory Adaptation of S1 Neurons" @default.
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- W2041304204 doi "https://doi.org/10.1523/jneurosci.2646-08.2008" @default.
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