FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041306599> ?p ?o ?g. }

• W2041306599 endingPage "271" @default.
• W2041306599 startingPage "257" @default.
• W2041306599 abstract "Species differences in the biotransformation of coumarin are thought to play an important role in its toxicity. Since the putative toxic metabolite is coumarin 3,4-epoxide (CE), methods to measure the metabolites of CE were developed. The glutathione (GSH) conjugate of CE (CE-SG) at the 3-position was purified by reversed-phase (RP)-high performance liquid chromatography (HPLC), and characterized by mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). An RP-HPLC method was developed to quantify CE-SG in hepatic microsomal mixtures and a separate RP-HPLC method was also developed to quantify the three ring-opened coumarin metabolites; o-hydroxyphenylacetic acid (o-HPAA), o-hydroxyphenylethanol (o-HPE) and o-hydroxyphenylacetaldehyde (o-HPA) in hepatic microsomal mixtures. Detection limits for all four products of coumarin epoxidation exceeded 3.5 ng/ml and recovery from hepatic microsomal mixtures was essentially quantitative with RSD values less than 8%. Species differences in o-HPA detoxification were consistent with sensitivity to coumarin, thereby demonstrating that these methods have utility in addressing the fate of CE and its contribution to toxicity." @default.
• W2041306599 created "2016-06-24" @default.
• W2041306599 creator A5001841002 @default.
• W2041306599 creator A5012141528 @default.
• W2041306599 creator A5014833273 @default.
• W2041306599 creator A5015166000 @default.
• W2041306599 creator A5028725177 @default.
• W2041306599 creator A5029178085 @default.
• W2041306599 date "2003-09-01" @default.
• W2041306599 modified "2023-10-05" @default.
• W2041306599 title "Liquid chromatographic determination of the glutathione conjugate and ring-opened metabolites formed from coumarin epoxidation" @default.
• W2041306599 cites W1581414347 @default.
• W2041306599 cites W1987585007 @default.
• W2041306599 cites W1991103586 @default.
• W2041306599 cites W1991467121 @default.
• W2041306599 cites W1993144720 @default.
• W2041306599 cites W1994482541 @default.
• W2041306599 cites W1994991733 @default.
• W2041306599 cites W2005548050 @default.
• W2041306599 cites W2007054543 @default.
• W2041306599 cites W2014509727 @default.
• W2041306599 cites W2016583849 @default.
• W2041306599 cites W2043343311 @default.
• W2041306599 cites W2064742171 @default.
• W2041306599 cites W2067510010 @default.
• W2041306599 cites W2076346268 @default.
• W2041306599 cites W2081146379 @default.
• W2041306599 cites W2088874275 @default.
• W2041306599 cites W2088980682 @default.
• W2041306599 cites W2091272725 @default.
• W2041306599 cites W2097559947 @default.
• W2041306599 cites W2127886348 @default.
• W2041306599 cites W2152619441 @default.
• W2041306599 cites W2216108125 @default.
• W2041306599 cites W2239879472 @default.
• W2041306599 cites W4293247451 @default.
• W2041306599 doi "https://doi.org/10.1016/s1570-0232(03)00473-2" @default.
• W2041306599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12954377" @default.
• W2041306599 hasPublicationYear "2003" @default.
• W2041306599 type Work @default.
• W2041306599 sameAs 2041306599 @default.
• W2041306599 citedByCount "17" @default.
• W2041306599 countsByYear W20413065992012 @default.
• W2041306599 countsByYear W20413065992013 @default.
• W2041306599 countsByYear W20413065992016 @default.
• W2041306599 countsByYear W20413065992019 @default.
• W2041306599 countsByYear W20413065992020 @default.
• W2041306599 countsByYear W20413065992021 @default.
• W2041306599 countsByYear W20413065992022 @default.
• W2041306599 crossrefType "journal-article" @default.
• W2041306599 hasAuthorship W2041306599A5001841002 @default.
• W2041306599 hasAuthorship W2041306599A5012141528 @default.
• W2041306599 hasAuthorship W2041306599A5014833273 @default.
• W2041306599 hasAuthorship W2041306599A5015166000 @default.
• W2041306599 hasAuthorship W2041306599A5028725177 @default.
• W2041306599 hasAuthorship W2041306599A5029178085 @default.
• W2041306599 hasConcept C134306372 @default.
• W2041306599 hasConcept C161790260 @default.
• W2041306599 hasConcept C162356407 @default.
• W2041306599 hasConcept C178790620 @default.
• W2041306599 hasConcept C179998833 @default.
• W2041306599 hasConcept C181199279 @default.
• W2041306599 hasConcept C185592680 @default.
• W2041306599 hasConcept C197336794 @default.
• W2041306599 hasConcept C2776524530 @default.
• W2041306599 hasConcept C2776920199 @default.
• W2041306599 hasConcept C2777477808 @default.
• W2041306599 hasConcept C2781338262 @default.
• W2041306599 hasConcept C27881333 @default.
• W2041306599 hasConcept C33923547 @default.
• W2041306599 hasConcept C43617362 @default.
• W2041306599 hasConcept C538909803 @default.
• W2041306599 hasConcept C55493867 @default.
• W2041306599 hasConcept C87644729 @default.
• W2041306599 hasConcept C95986675 @default.
• W2041306599 hasConceptScore W2041306599C134306372 @default.
• W2041306599 hasConceptScore W2041306599C161790260 @default.
• W2041306599 hasConceptScore W2041306599C162356407 @default.
• W2041306599 hasConceptScore W2041306599C178790620 @default.
• W2041306599 hasConceptScore W2041306599C179998833 @default.
• W2041306599 hasConceptScore W2041306599C181199279 @default.
• W2041306599 hasConceptScore W2041306599C185592680 @default.
• W2041306599 hasConceptScore W2041306599C197336794 @default.
• W2041306599 hasConceptScore W2041306599C2776524530 @default.
• W2041306599 hasConceptScore W2041306599C2776920199 @default.
• W2041306599 hasConceptScore W2041306599C2777477808 @default.
• W2041306599 hasConceptScore W2041306599C2781338262 @default.
• W2041306599 hasConceptScore W2041306599C27881333 @default.
• W2041306599 hasConceptScore W2041306599C33923547 @default.
• W2041306599 hasConceptScore W2041306599C43617362 @default.
• W2041306599 hasConceptScore W2041306599C538909803 @default.
• W2041306599 hasConceptScore W2041306599C55493867 @default.
• W2041306599 hasConceptScore W2041306599C87644729 @default.
• W2041306599 hasConceptScore W2041306599C95986675 @default.
• W2041306599 hasIssue "2" @default.
• W2041306599 hasLocation W20413065991 @default.
• W2041306599 hasLocation W20413065992 @default.
• W2041306599 hasOpenAccess W2041306599 @default.

• next