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- W2041314095 abstract "Recently, attempts have been made to harmonize and simplify the nomenclature and abbreviations for inositol derivatives of biological importance, chiefly lipids and a variety of isomeric phosphates. The simplest suggestion was made by participants at the 1984 Chilton Conference (Agranoff et al. 1984). They proposed reducing the relatively cumbersome IUB/IUPAC-recommended abbreviations (e.g. PtdIns(4,5)P 2 for phosphatidylinositol 4,5- bisphosphate, and Ins(1,4,5) P3for inositol 1,4,5-trisphosphate) to much simpler and easily spoken alternatives (PIP 2 and IP 3 for the above compounds). This proposal was simple and attractive at the time, but it was immediately rendered obsolete by the discovery of inositol 1,3,4-trisphosphate, which would have had to share a Chilton abbreviation with inositol 1,4,5- trisphosphate from which it is derived. To add to this potential confusion, we now have to contend with a minimum of three inositol tetrakisphosphate isomers. Following this meeting, we must also have distinct abbreviations for phosphatidylinositol 3-phosphate and phosphatidylinositol 4-phosphate: they cannot share PIP. ‘Modified Chilton’ systems that retain the brevity implicit in using an initial P to represent ‘phosphatidyl’ and I to represent ‘inositol’ have since been used in some publications (e.g. PI(4,5)P 2 for phosphatidylinositol 4,5- bisphosphate, and I(1,4,5)P 3 or (1,4,5)IP 3 for inositol 1,4,5-trisphosphate). However, these are cumbersome to speak and have important disadvantages. ‘ I ’ is the accepted abbreviation for inosine, which also forms phosphate derivatives that have their own abbreviations (e.g. ITP), and bad typing often confuses I with 1; and, at least for the lipids, a capital P has two meanings within a single abbreviation, namely phosphatidyl (which should be a roman capital P) and phosphate (which should be italic)." @default.
- W2041314095 created "2016-06-24" @default.
- W2041314095 date "1988-07-26" @default.
- W2041314095 modified "2023-10-18" @default.
- W2041314095 title "A comment on nomenclature and abbreviations" @default.
- W2041314095 doi "https://doi.org/10.1098/rstb.1988.0073" @default.
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