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• W2041327679 endingPage "2220" @default.
• W2041327679 startingPage "2208" @default.
• W2041327679 abstract "Preclinical data, and an increasing list of clinical investigations, show anti-inflammatory agents to favourably influence the biology of colorectal tumor. We have earlier reported on re-expression of activated immune cells after three days preoperative treatment of patients with colorectal carcinoma, randomized to receive oral NSAID (indomethacin or celebrex). Antisecretory prophylaxis (esomeprasol) was provided to all patients and served as sham treatment. Concomittant to MHC locus activation, Prominin1/CD133, a marker associated with stemness and poor prognosis in several solid tumors, was downregulated. The aim of the present study was to evaluate expression of additional regulators belonging to the stem cell niche, OCT4, SOX2 and BMP7, as well as some microRNAs, reported to act as tumor suppressors or oncomiRs. Peroperative tumor biopsies were analyzed by microarrays, quantitative real-time PCR and immunohistochemistry (IHC). The stem cell master regulator SOX2 was increased by NSAIDs (p<0.01), as well as the tumor suppressor miR-630 (p<0.01), while BMP7, a marker for poor prognosis in CRC, was downregulated by NSAID (indomethacin, p<0.02). The upregulation of SOX2, but not of its heterodimer binding partner OCT4, could imply a negative feed-back loop, with a switch‑off for stemness preservation of tumor cells. This is supported by the overall evaluation of gene expression profiles with subsequent events, indicating less aggressive tumors following NSAID treatment." @default.
• W2041327679 created "2016-06-24" @default.
• W2041327679 creator A5037536856 @default.
• W2041327679 creator A5049306688 @default.
• W2041327679 creator A5052391213 @default.
• W2041327679 creator A5064972642 @default.
• W2041327679 creator A5067533558 @default.
• W2041327679 date "2014-09-30" @default.
• W2041327679 modified "2023-10-17" @default.
• W2041327679 title "Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer" @default.
• W2041327679 cites W1483818316 @default.
• W2041327679 cites W1487353108 @default.
• W2041327679 cites W1556550066 @default.
• W2041327679 cites W1608762409 @default.
• W2041327679 cites W1744006947 @default.
• W2041327679 cites W1877598057 @default.
• W2041327679 cites W1884084176 @default.
• W2041327679 cites W1890778551 @default.
• W2041327679 cites W1956721442 @default.
• W2041327679 cites W1969179633 @default.
• W2041327679 cites W1973146690 @default.
• W2041327679 cites W1979728706 @default.
• W2041327679 cites W1981053693 @default.
• W2041327679 cites W1986214281 @default.
• W2041327679 cites W1986506670 @default.
• W2041327679 cites W1989421786 @default.
• W2041327679 cites W1992497862 @default.
• W2041327679 cites W1993046567 @default.
• W2041327679 cites W1998864452 @default.
• W2041327679 cites W2000098894 @default.
• W2041327679 cites W2001073369 @default.
• W2041327679 cites W2003762247 @default.
• W2041327679 cites W2008697920 @default.
• W2041327679 cites W2010164793 @default.
• W2041327679 cites W2010661790 @default.
• W2041327679 cites W2013782861 @default.
• W2041327679 cites W2014882841 @default.
• W2041327679 cites W2018760796 @default.
• W2041327679 cites W2019950666 @default.
• W2041327679 cites W2022915997 @default.
• W2041327679 cites W2023206857 @default.
• W2041327679 cites W2025069710 @default.
• W2041327679 cites W2026838378 @default.
• W2041327679 cites W2030273625 @default.
• W2041327679 cites W2032880981 @default.
• W2041327679 cites W2035301218 @default.
• W2041327679 cites W2039553809 @default.
• W2041327679 cites W2040191060 @default.
• W2041327679 cites W2040884950 @default.
• W2041327679 cites W2042907812 @default.
• W2041327679 cites W2044833878 @default.
• W2041327679 cites W2046811422 @default.
• W2041327679 cites W2047131872 @default.
• W2041327679 cites W2052677854 @default.
• W2041327679 cites W2054872825 @default.
• W2041327679 cites W2056550887 @default.
• W2041327679 cites W2058245162 @default.
• W2041327679 cites W2058418464 @default.
• W2041327679 cites W2059746106 @default.
• W2041327679 cites W2060977199 @default.
• W2041327679 cites W2064220583 @default.
• W2041327679 cites W2064407305 @default.
• W2041327679 cites W2065550928 @default.
• W2041327679 cites W2068978328 @default.
• W2041327679 cites W2072472629 @default.
• W2041327679 cites W2076316598 @default.
• W2041327679 cites W2078329024 @default.
• W2041327679 cites W2084343793 @default.
• W2041327679 cites W2086160302 @default.
• W2041327679 cites W2088645831 @default.
• W2041327679 cites W2090673274 @default.
• W2041327679 cites W2094754107 @default.
• W2041327679 cites W2100851348 @default.
• W2041327679 cites W2102559055 @default.
• W2041327679 cites W2103192556 @default.
• W2041327679 cites W2103955948 @default.
• W2041327679 cites W2105397361 @default.
• W2041327679 cites W2110224954 @default.
• W2041327679 cites W2122447839 @default.
• W2041327679 cites W2123032057 @default.
• W2041327679 cites W2123414352 @default.
• W2041327679 cites W2123776269 @default.
• W2041327679 cites W2125054151 @default.
• W2041327679 cites W2129884254 @default.
• W2041327679 cites W2131713471 @default.
• W2041327679 cites W2132237956 @default.
• W2041327679 cites W2134021858 @default.
• W2041327679 cites W2134189685 @default.
• W2041327679 cites W2137520566 @default.
• W2041327679 cites W2141437534 @default.
• W2041327679 cites W2141806195 @default.
• W2041327679 cites W2144979911 @default.
• W2041327679 cites W2145435609 @default.
• W2041327679 cites W2145864981 @default.
• W2041327679 cites W2148284146 @default.
• W2041327679 cites W2154458783 @default.
• W2041327679 cites W2156385497 @default.
• W2041327679 cites W2158547522 @default.

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