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- W2041329246 abstract "The subcellualr localization of cis-dichlorodiammineplatinum(II) (cisplatin), an anticancer agent, was analyzed in rat kidney and compared to that in liver over a period of 72 hr. Male F-344 rats were given a dose of cisplatin (7 mg/kg), ip, and five subcellular fractions were isolated by differential centrifugation. Based on atomic absorption spectrometry of platinum, it was found that the kidney accumulated a greater concentration of cisplatin with a longer biological half-life than the liver. On a subcellular level, cisplatin showed a significantly high affinity for nuclei and microsomes in the kidney but not in the liver. At 24 hr, platinum concentrations were 550 ng/mg protein in the nuclear fraction (14% of total platinum) and 420 ng/mg protein in the microsomal fraction in the kidney. The cytosol contained the largest quantity of platinum (∼70%) in the kidney, of which about 40% was precipitable by trichloroacetic acid. However, the specific concentration of platinum in the acid precipitate of the cytosol was less than that of nuclei or microsomes in the kidney. Renal mitochondria and plasma membranes were associated with low concentrations of platinum. These results suggest that nuclei and microsomes may be primary target sites for cisplatin in the kidney." @default.
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- W2041329246 date "1980-09-01" @default.
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- W2041329246 title "Subcellular localization of cis-dichlorodiammineplatinum(II) in rat kidney and liver" @default.
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- W2041329246 doi "https://doi.org/10.1016/0041-008x(80)90086-1" @default.
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