FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041344324> ?p ?o ?g. }

• W2041344324 endingPage "477" @default.
• W2041344324 startingPage "472" @default.
• W2041344324 abstract "The high-affinity IgA1 toward jacalin was mostly composed of aggregated IgA1 and abundantly contained the asialo disaccharide, Galbeta1,3GalNAc, in the O-linked oligosaccharide in the hinge region [Journal of Biochemistry 120, 92-97 (1996)]. Meanwhile, the removal of sialic acid from IgA1 accelerated the aggregation of the IgA1 molecule [J. Am. Soc. Nephrol. 9, 2048-2054 (1998)]. In order to examine the nature of such a sticky IgA1, affinity chromatography using asialo-IgA1 (deSIgA1)-Sepharose was carried out. Seventeen percent of normal human serum IgA1, 27% of asialo-IgA1 (IgA1-S), and 48% of asialo-, agalacto-IgA1 (IgA1-SG) were bound to the column. Removal of the N-acetylgalactosamine residue from IgA1-SG resulted in a decreasing affinity toward deSIgA1-Sepharose. Thus, the binding ability toward the column was the highest for the IgA1-SG among the deglycosylated IgA1s. On the other hand, heat treatment of IgA1 accelerated the aggregation but decreased its binding ability toward the column. Such heat denaturation probably destroys the structure of the binding site. Since the enzymatic removal of the N-glycan sugar chains did not induce the aggregation and exhibited no effect on the binding, the incomplete O-linked sugar chain on the hinge portion should be directly related to the sticky characteristics of the IgA1 molecule. The binding was non-covalent and not strong because the asialo-, agalacto-hinge glycopeptide was eluted slightly slower than the native one from the column and the bound IgA1 was dissociated in the presence of 1 M NaCl." @default.
• W2041344324 created "2016-06-24" @default.
• W2041344324 creator A5007615977 @default.
• W2041344324 creator A5009626259 @default.
• W2041344324 creator A5013862834 @default.
• W2041344324 creator A5016077468 @default.
• W2041344324 creator A5036578647 @default.
• W2041344324 creator A5055366659 @default.
• W2041344324 creator A5065436629 @default.
• W2041344324 creator A5068010875 @default.
• W2041344324 creator A5071679239 @default.
• W2041344324 creator A5077643737 @default.
• W2041344324 date "1999-08-01" @default.
• W2041344324 modified "2023-10-07" @default.
• W2041344324 title "Study of the Relationship between Sticky Human Serum IgA1 and Its O-Glycan Glycoform" @default.
• W2041344324 cites W1528669392 @default.
• W2041344324 cites W1566307488 @default.
• W2041344324 cites W1967644732 @default.
• W2041344324 cites W1975362922 @default.
• W2041344324 cites W1986005204 @default.
• W2041344324 cites W1992322707 @default.
• W2041344324 cites W2005773350 @default.
• W2041344324 cites W2027012341 @default.
• W2041344324 cites W2031884020 @default.
• W2041344324 cites W2058342949 @default.
• W2041344324 cites W2065363210 @default.
• W2041344324 cites W2077851831 @default.
• W2041344324 cites W2079344868 @default.
• W2041344324 cites W2081935297 @default.
• W2041344324 cites W2088407845 @default.
• W2041344324 cites W2099377647 @default.
• W2041344324 cites W2100063226 @default.
• W2041344324 cites W2125247444 @default.
• W2041344324 cites W2143014918 @default.
• W2041344324 cites W2156501795 @default.
• W2041344324 cites W2262508674 @default.
• W2041344324 cites W2296703812 @default.
• W2041344324 cites W2319451394 @default.
• W2041344324 cites W2344924939 @default.
• W2041344324 cites W2911450783 @default.
• W2041344324 cites W4236616365 @default.
• W2041344324 doi "https://doi.org/10.1006/bbrc.1999.1006" @default.
• W2041344324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10425209" @default.
• W2041344324 hasPublicationYear "1999" @default.
• W2041344324 type Work @default.
• W2041344324 sameAs 2041344324 @default.
• W2041344324 citedByCount "22" @default.
• W2041344324 countsByYear W20413443242018 @default.
• W2041344324 crossrefType "journal-article" @default.
• W2041344324 hasAuthorship W2041344324A5007615977 @default.
• W2041344324 hasAuthorship W2041344324A5009626259 @default.
• W2041344324 hasAuthorship W2041344324A5013862834 @default.
• W2041344324 hasAuthorship W2041344324A5016077468 @default.
• W2041344324 hasAuthorship W2041344324A5036578647 @default.
• W2041344324 hasAuthorship W2041344324A5055366659 @default.
• W2041344324 hasAuthorship W2041344324A5065436629 @default.
• W2041344324 hasAuthorship W2041344324A5068010875 @default.
• W2041344324 hasAuthorship W2041344324A5071679239 @default.
• W2041344324 hasAuthorship W2041344324A5077643737 @default.
• W2041344324 hasConcept C108625454 @default.
• W2041344324 hasConcept C137610392 @default.
• W2041344324 hasConcept C178790620 @default.
• W2041344324 hasConcept C179247698 @default.
• W2041344324 hasConcept C180577832 @default.
• W2041344324 hasConcept C181199279 @default.
• W2041344324 hasConcept C185592680 @default.
• W2041344324 hasConcept C206212055 @default.
• W2041344324 hasConcept C2776600866 @default.
• W2041344324 hasConcept C2777726330 @default.
• W2041344324 hasConcept C2779881004 @default.
• W2041344324 hasConcept C2780115458 @default.
• W2041344324 hasConcept C43617362 @default.
• W2041344324 hasConcept C501593827 @default.
• W2041344324 hasConcept C55493867 @default.
• W2041344324 hasConceptScore W2041344324C108625454 @default.
• W2041344324 hasConceptScore W2041344324C137610392 @default.
• W2041344324 hasConceptScore W2041344324C178790620 @default.
• W2041344324 hasConceptScore W2041344324C179247698 @default.
• W2041344324 hasConceptScore W2041344324C180577832 @default.
• W2041344324 hasConceptScore W2041344324C181199279 @default.
• W2041344324 hasConceptScore W2041344324C185592680 @default.
• W2041344324 hasConceptScore W2041344324C206212055 @default.
• W2041344324 hasConceptScore W2041344324C2776600866 @default.
• W2041344324 hasConceptScore W2041344324C2777726330 @default.
• W2041344324 hasConceptScore W2041344324C2779881004 @default.
• W2041344324 hasConceptScore W2041344324C2780115458 @default.
• W2041344324 hasConceptScore W2041344324C43617362 @default.
• W2041344324 hasConceptScore W2041344324C501593827 @default.
• W2041344324 hasConceptScore W2041344324C55493867 @default.
• W2041344324 hasIssue "2" @default.
• W2041344324 hasLocation W20413443241 @default.
• W2041344324 hasLocation W20413443242 @default.
• W2041344324 hasOpenAccess W2041344324 @default.
• W2041344324 hasPrimaryLocation W20413443241 @default.
• W2041344324 hasRelatedWork W13837555 @default.
• W2041344324 hasRelatedWork W1917539558 @default.
• W2041344324 hasRelatedWork W1987484892 @default.
• W2041344324 hasRelatedWork W2018887770 @default.

• next