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• W2041352783 abstract "1. The ionized cytosolic calcium concentration ([Ca2+]i) was monitored in voltage-clamped coronary myocytes at 36 degrees C and 2.5 mM [Ca2+]o using the Ca2+ indicator indo-1. [Ca2+]i was transiently increased by fast application of 10 mM caffeine, and the mechanisms involved in decay of [Ca2+]i were analysed. 2. Resting [Ca2+]i was 166 +/- 62 nM (mean +/- S.D.). Caffeine increased [Ca2+]i within 1-2 s to 1618 +/- 490 nM. In the continuous presence of caffeine [Ca2+]i fell close to resting values with a half-decay time of 5.0 +/- 1.6 s. Wash-out of caffeine induced an undershoot of [Ca2+]i to 105 +/- 30 nM. When caffeine was applied repetitively the [Ca2+]i transients were of reduced amplitude indicating that the store had lost a part of releasable Ca2+. 3. After a 1 s caffeine application [Ca2+]i decayed with a half-time of 2.3 +/- 0.8 s to the undershoot of 112 +/- 57 nM. The decay of [Ca2+]i was largely prevented by 3 mM [La3+]o; after wash-out of La3+ [Ca2+]i fell to the resting value without an undershoot. The results demonstrate that La(3+)-sensitive Ca2+ extrusion contributes to the decay of the [Ca2+]i transient and to the undershoot. 4. With 10 mM [Na+]i, sodium removal from the bath incremented [Ca2+]i in three out of ten cells by 71 +/- 11 nM; in the other cells [Ca2+]i did not change. In the absence of extracellular sodium the decay of [Ca2+]i after wash-out of caffeine was not retarded. 5. To stimulate Na(+)-Ca2+ exchange, cells were dialysed with pipette solution containing 150 mM NaCl. Elevation of [Na+]i had no significant effect on the resting [Ca2+]i (180 +/- 47 nM) or on the caffeine-induced [Ca2+]i transients (peak 1614 +/- 530 nM, half-time of decay 3 s, undershoot 107 +/- 40 nM). 6. With 150 mM [Na+]i, sodium removal resulted in an increase of [Ca2+]i, although responses varied in amplitude (from 130 to 2300 nM) and rate of rise. In the absence of sodium [Ca2+]i remained elevated. After a 1 s caffeine application the undershoot of [Ca2+]i was abolished in sodium-free solution. When caffeine was applied in sodium-free solution, the [Ca2+]i transient decayed to a sustained level and the following caffeine response was attenuated. 7. With 150 mM [Na+]i, the effects of sodium removal were strongly suppressed by a preceding depletion of the Ca2+ stores with caffeine. Ryanodine pretreatment abolished the caffeine-induced [Ca2+]i transients and reduced [Ca2+]i response due to sodium removal.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
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• W2041352783 date "1993-08-01" @default.
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• W2041352783 title "Ca2+ entry through Na(+)-Ca2+ exchange can trigger Ca2+ release from Ca2+ stores in Na(+)-loaded guinea-pig coronary myocytes." @default.
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• W2041352783 doi "https://doi.org/10.1113/jphysiol.1993.sp019768" @default.
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