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- W2041357642 abstract "Somatostatin is a peptide synthesized in many tissues that can act as a neurotransmitter, a systemic hormone, or a local hormone, and inhibits the secretion of hormones or other cell products. A long-acting synthetic analogue of somatostatin (SMS 201-995) has been developed which when administered subcutaneously has a biologic half-life of 90 to 120 minutes and can be administered 2 or 3 times per day. SMS 201-995 can lower plasma concentrations of growth hormone and somatomedin-C in patients with pituitary acromegaly, but no controlled trials to assess symptomatic response or change in tumor size have been done. In patients with pituitary thyrotropin-producing pituitary tumors, SMS 201-995 has been remarkably effective in producing biochemical and clinical responses and is the drug of first choice in this syndrome when tumor resection is not possible. In patients with the carcinoid syndrome, SMS 201-995 effectively reduces diarrhea, is the best available drug for treatment of carcinoid flush (effective in approximately 90% of cases), and is useful in treating carcinoid crisis. Eighty-five percent of patients with pancreatic islet cell tumors that produce vasoactive intestinal peptide will respond to SMS 201-995 with a reduction in diarrhea that often has been resistant to all other therapy. SMS 201-995 may also be useful in treating the symptoms in some patients with glucagonomas, growth hormone releasing hormone-producing tumors and insulinomas. Whether SMS 201-995 has a significant effect on gut neuroendocrine tumor growth remains uncertain. Certain nonmalignant diseases of the gut respond to somatostatin, including secretory diarrhea and fistulas of unknown cause. In general, SMS 201-995 has proved safe with few significant side effects, but whether the long-term use of the drug will result in an iatrogenic form of the somatostatinoma syndrome is uncertain." @default.
- W2041357642 created "2016-06-24" @default.
- W2041357642 creator A5008524910 @default.
- W2041357642 creator A5031916299 @default.
- W2041357642 creator A5035014391 @default.
- W2041357642 creator A5070064147 @default.
- W2041357642 date "1989-01-01" @default.
- W2041357642 modified "2023-09-30" @default.
- W2041357642 title "Somatostatin and Somatostatin Analogue (SMS 201-995) in Treatment of Hormone-Secreting Tumors of the Pituitary and Gastrointestinal Tract and Non-Neoplastic Diseases of the Gut" @default.
- W2041357642 cites W122184333 @default.
- W2041357642 cites W145149749 @default.
- W2041357642 cites W149607129 @default.
- W2041357642 cites W1548807928 @default.
- W2041357642 cites W1964747228 @default.
- W2041357642 cites W1965134855 @default.
- W2041357642 cites W1965478841 @default.
- W2041357642 cites W1966660659 @default.
- W2041357642 cites W1967449771 @default.
- W2041357642 cites W1971335668 @default.
- W2041357642 cites W1971585040 @default.
- W2041357642 cites W1972564195 @default.
- W2041357642 cites W1974492914 @default.
- W2041357642 cites W1975003149 @default.
- W2041357642 cites W1986146493 @default.
- W2041357642 cites W1987773213 @default.
- W2041357642 cites W1988304423 @default.
- W2041357642 cites W1988418236 @default.
- W2041357642 cites W1989883614 @default.
- W2041357642 cites W1994660214 @default.
- W2041357642 cites W1995956817 @default.
- W2041357642 cites W1999340443 @default.
- W2041357642 cites W2005112918 @default.
- W2041357642 cites W2005518939 @default.
- W2041357642 cites W2005614064 @default.
- W2041357642 cites W2006611896 @default.
- W2041357642 cites W2009059575 @default.
- W2041357642 cites W2009318088 @default.
- W2041357642 cites W2014108955 @default.
- W2041357642 cites W2015609597 @default.
- W2041357642 cites W2016755579 @default.
- W2041357642 cites W2017829408 @default.
- W2041357642 cites W2019261163 @default.
- W2041357642 cites W2021958010 @default.
- W2041357642 cites W2026528731 @default.
- W2041357642 cites W2030738368 @default.
- W2041357642 cites W2031403762 @default.
- W2041357642 cites W2032522232 @default.
- W2041357642 cites W2035456976 @default.
- W2041357642 cites W2035865302 @default.
- W2041357642 cites W2037147471 @default.
- W2041357642 cites W2037232466 @default.
- W2041357642 cites W2038594553 @default.
- W2041357642 cites W2039670609 @default.
- W2041357642 cites W2039722503 @default.
- W2041357642 cites W2042909936 @default.
- W2041357642 cites W2043275746 @default.
- W2041357642 cites W2044251662 @default.
- W2041357642 cites W2046187870 @default.
- W2041357642 cites W2046857215 @default.
- W2041357642 cites W2047595774 @default.
- W2041357642 cites W2047702417 @default.
- W2041357642 cites W2047727152 @default.
- W2041357642 cites W2048027889 @default.
- W2041357642 cites W2048659286 @default.
- W2041357642 cites W2049577149 @default.
- W2041357642 cites W2052944345 @default.
- W2041357642 cites W2057468394 @default.
- W2041357642 cites W2060185962 @default.
- W2041357642 cites W2061530598 @default.
- W2041357642 cites W2063752654 @default.
- W2041357642 cites W2064395050 @default.
- W2041357642 cites W2064544402 @default.
- W2041357642 cites W2065789177 @default.
- W2041357642 cites W2066859610 @default.
- W2041357642 cites W2067086939 @default.
- W2041357642 cites W2067393305 @default.
- W2041357642 cites W2068376010 @default.
- W2041357642 cites W2068671797 @default.
- W2041357642 cites W2069087191 @default.
- W2041357642 cites W2069306645 @default.
- W2041357642 cites W2069697404 @default.
- W2041357642 cites W2071310612 @default.
- W2041357642 cites W2073586440 @default.
- W2041357642 cites W2075335259 @default.
- W2041357642 cites W2075359966 @default.
- W2041357642 cites W2079849586 @default.
- W2041357642 cites W2082245953 @default.
- W2041357642 cites W2082636225 @default.
- W2041357642 cites W2082837694 @default.
- W2041357642 cites W2086646813 @default.
- W2041357642 cites W2087992700 @default.
- W2041357642 cites W2088717006 @default.
- W2041357642 cites W2090065340 @default.
- W2041357642 cites W2111429368 @default.
- W2041357642 cites W2118665973 @default.
- W2041357642 cites W2122946427 @default.
- W2041357642 cites W2124477194 @default.
- W2041357642 cites W2130211795 @default.