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• W2041359990 abstract "<h3>ABSTRACT</h3> Silver nanoparticles (AgNP) are widely used in consumer products, mostly due to their excellent antimicrobial properties. One of the well-established antibacterial mechanisms of AgNP is their efficient contact with bacteria and dissolution on cell membranes. To our knowledge, the primary mechanism of cell wall damage and the event(s) initiating bactericidal action of AgNP are not yet elucidated. In this study we used a combination of different assays to reveal the effect of AgNP on i) bacterial envelope in general, ii) outer membrane (OM) and iii) on plasma membrane (PM). We showed that bacterial PM was the main target of AgNP in Gram-negative bacteria <i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>. AgNP depolarized bacterial PM, induced the leakage of the intracellular K⁺, inhibited respiration and caused the depletion of the intracellular ATP. In contrast, AgNP had no significant effect on the bacterial OM. Most of the adverse effects on bacterial envelope and PM occurred within the seconds and in the concentration range of 7-160 μM AgNP, depending on the bacteria and assay used, while irreversible inhibition of bacterial growth (minimal bactericidal concentration after 1-h exposure of bacteria to AgNP) occurred at 40 μM AgNP for <i>P. aeruginosa</i> and at 320 μM AgNP for <i>E. coli</i>. Flow cytometry analysis showed that AgNP were binding to <i>P. aeruginosa</i> but not to <i>E. coli</i> cells and were found inside the <i>P. aeruginosa</i> cells. Taking into account that AgNP did not damage OM, we speculate that AgNP entered <i>P. aeruginosa via</i> specific mechanism, e.g., transport through porins." @default.
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• W2041359990 date "2011-07-19" @default.
• W2041359990 modified "2023-10-14" @default.
• W2041359990 title "The Watery Eye" @default.
• W2041359990 doi "https://doi.org/10.1136/bmj.d4029" @default.
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