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- W2041368279 abstract "Current treatment of solid tumors is limited by side effects that result from the non-specific delivery of drugs to the tumor site. Alternative targeted therapeutic approaches for localized tumors would significantly reduce systemic toxicity. Peptide therapeutics are a promising new strategy for targeted cancer therapy because of the ease of peptide design and the specificity of peptides for their intracellular molecular targets. However, the utility of peptides is limited by their poor pharmacokinetic parameters and poor tissue and cellular membrane permeability in vivo. This review article summarizes the development of elastin-like polypeptide (ELP) as a potential carrier for thermally targeted delivery of therapeutic peptides (TP), and the use of cell penetrating peptides (CPP) to enhance the intracellular delivery of the ELP-fused TPs. CPP-fused ELPs have been used to deliver a peptide inhibitor of c-Myc function and a peptide mimetic of p21 in several cancer models in vitro, and both polypeptides are currently yielding promising results in in vivo models of breast and brain cancer." @default.
- W2041368279 created "2016-06-24" @default.
- W2041368279 creator A5034262384 @default.
- W2041368279 creator A5073630613 @default.
- W2041368279 date "2010-12-01" @default.
- W2041368279 modified "2023-09-25" @default.
- W2041368279 title "Cell penetrating elastin-like polypeptides for therapeutic peptide delivery" @default.
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- W2041368279 doi "https://doi.org/10.1016/j.addr.2010.05.003" @default.
- W2041368279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2964383" @default.
- W2041368279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20478348" @default.
- W2041368279 hasPublicationYear "2010" @default.
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