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• W2041371021 abstract "The present study aims to evaluate Cordyceps militaris water extract (CMWE) with a view to develop melanogenesis inhibitors. Inhibitory activities of CMWE against tyrosinase, L-DOPA(L-3,4-dihydroxyphenylalanine) oxidation, and melanin biosynthesis in B16 mouse melanoma cells were investigated. CMWE, at 5000 μg/ml, inhibited tyrosinase activity of 71% and DOPA oxidation of 40% as reacting with L-DOPA. Furthermore, B16 mouse melanoma cell survived over 50% from low to high dose on MTT assay, and CMWE markedly inhibited (>50%) melanin synthesis at 5000 μg/ml. The inhibitory effect of CMWE on melanogenesis was attributed to enhancement of tyrosinase degradation. Key enzyme of melanin biosynthesis is tyrosinase which catalyses a beginning step from tyrosine to DOPA quinine and melanin formation step, respectively. These results indicated that CMWE may be a potential source of novel whitening agents for cosmetic or therapeutic application." @default.
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• W2041371021 date "2010-12-31" @default.
• W2041371021 modified "2023-09-25" @default.
• W2041371021 title "Inhibitory Effects of Melanin Secretion on B16 Melanoma cell of Cordyceps militaris Water Extract" @default.
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• W2041371021 doi "https://doi.org/10.4489/kjm.2010.38.2.167" @default.
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