Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041374629> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2041374629 endingPage "2140" @default.
- W2041374629 startingPage "2133" @default.
- W2041374629 abstract "Abstract BCNU [1,3 bis-(2-chloroethyl)-1-nitrosourea] and some related nitrosoureas have been shown to have a wide spectrum of action against a number of transplanted rodent tumours. No correlation was found between the chemical instability of a nitrosourea and its antitumour activity. Unlike difunctional alkylating agents, the nitrosoureas inhibit the incorporation of tritiated precursors in DNA, RNA and protein to equal extents, the inhibition of tritiated thymidine incorporation into DNA occurring within 5 min of incubating cells with BCNU. Although the biological half life of BCNU was found to be very short (15 min by bioassay) a single injection was as effective against the established and widely-disseminated TLX5 lymphoma as against the early transplant. BCNU interfered specifically with the incorporation of labelled thymidine triphosphate into DNA, but no inhibition of DNA polymerase could be demonstrated at physiological dose levels. In their mechanism of action and in their biological properties the tumour inhibitory nitrosoureas are quite distinct from the bifunctional alkylating agents." @default.
- W2041374629 created "2016-06-24" @default.
- W2041374629 creator A5056997693 @default.
- W2041374629 creator A5079711951 @default.
- W2041374629 date "1975-12-01" @default.
- W2041374629 modified "2023-10-14" @default.
- W2041374629 title "Studies of the mechanism of action of the tumour-inhibitory nitrosoureas" @default.
- W2041374629 cites W1595148502 @default.
- W2041374629 cites W1981863853 @default.
- W2041374629 cites W2000792342 @default.
- W2041374629 cites W2001340011 @default.
- W2041374629 cites W2030764175 @default.
- W2041374629 cites W2035981374 @default.
- W2041374629 cites W2068452566 @default.
- W2041374629 cites W2079741711 @default.
- W2041374629 cites W2092089811 @default.
- W2041374629 cites W2161314918 @default.
- W2041374629 cites W2313086702 @default.
- W2041374629 cites W2315737152 @default.
- W2041374629 doi "https://doi.org/10.1016/0006-2952(75)90042-8" @default.
- W2041374629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1212261" @default.
- W2041374629 hasPublicationYear "1975" @default.
- W2041374629 type Work @default.
- W2041374629 sameAs 2041374629 @default.
- W2041374629 citedByCount "11" @default.
- W2041374629 crossrefType "journal-article" @default.
- W2041374629 hasAuthorship W2041374629A5056997693 @default.
- W2041374629 hasAuthorship W2041374629A5079711951 @default.
- W2041374629 hasConcept C111472728 @default.
- W2041374629 hasConcept C121332964 @default.
- W2041374629 hasConcept C138885662 @default.
- W2041374629 hasConcept C169760540 @default.
- W2041374629 hasConcept C17077164 @default.
- W2041374629 hasConcept C185592680 @default.
- W2041374629 hasConcept C202751555 @default.
- W2041374629 hasConcept C2776120743 @default.
- W2041374629 hasConcept C2780791683 @default.
- W2041374629 hasConcept C55493867 @default.
- W2041374629 hasConcept C62520636 @default.
- W2041374629 hasConcept C86803240 @default.
- W2041374629 hasConcept C89611455 @default.
- W2041374629 hasConcept C98274493 @default.
- W2041374629 hasConceptScore W2041374629C111472728 @default.
- W2041374629 hasConceptScore W2041374629C121332964 @default.
- W2041374629 hasConceptScore W2041374629C138885662 @default.
- W2041374629 hasConceptScore W2041374629C169760540 @default.
- W2041374629 hasConceptScore W2041374629C17077164 @default.
- W2041374629 hasConceptScore W2041374629C185592680 @default.
- W2041374629 hasConceptScore W2041374629C202751555 @default.
- W2041374629 hasConceptScore W2041374629C2776120743 @default.
- W2041374629 hasConceptScore W2041374629C2780791683 @default.
- W2041374629 hasConceptScore W2041374629C55493867 @default.
- W2041374629 hasConceptScore W2041374629C62520636 @default.
- W2041374629 hasConceptScore W2041374629C86803240 @default.
- W2041374629 hasConceptScore W2041374629C89611455 @default.
- W2041374629 hasConceptScore W2041374629C98274493 @default.
- W2041374629 hasIssue "23" @default.
- W2041374629 hasLocation W20413746291 @default.
- W2041374629 hasLocation W20413746292 @default.
- W2041374629 hasOpenAccess W2041374629 @default.
- W2041374629 hasPrimaryLocation W20413746291 @default.
- W2041374629 hasRelatedWork W1964722019 @default.
- W2041374629 hasRelatedWork W1996335063 @default.
- W2041374629 hasRelatedWork W2003623666 @default.
- W2041374629 hasRelatedWork W2320217082 @default.
- W2041374629 hasRelatedWork W2343911421 @default.
- W2041374629 hasRelatedWork W2346662740 @default.
- W2041374629 hasRelatedWork W2418561632 @default.
- W2041374629 hasRelatedWork W2547865373 @default.
- W2041374629 hasRelatedWork W2751847892 @default.
- W2041374629 hasRelatedWork W2951867754 @default.
- W2041374629 hasVolume "24" @default.
- W2041374629 isParatext "false" @default.
- W2041374629 isRetracted "false" @default.
- W2041374629 magId "2041374629" @default.
- W2041374629 workType "article" @default.