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• W2041406567 abstract "Schizophrenia (SCZ) is a mental disease that affects approximately 1% of the population with life-long devastating consequences. Based on evidence for a major contribution of genetic factors, a decade of extensive efforts has been dedicated to the search of DNA sequence variations that increase the risk to SCZ. Search for genes in rare multiplex SCZ families with a large number of affected individuals and quasi-Mendelian mode of inheritance using genetic linkage methodology has been one of the favorite strategies in psychiatric genetics. Although several genomic regions were suggested for linkage to SCZ, not a single gene causing or predisposing to SCZ has been identified thus far. Furthermore, it is not clear whether the genes of familial SCZ are also involved in sporadic cases that represent the overwhelming majority of SCZ patients. For sporadic cases, genetic association studies comparing the distribution of allelic frequencies of candidate genes in SCZ patients and controls have been performed but the outcome of such studies has also been quite modest. Several factors such as possible involvement of numerous interactive genes of minor effect, yet unknown environmental effects and diagnostic ambiguities of the disease have made genetic studies in SCZ quite unproductive. In terms of future studies, a genome-wide association search is a promising approach; however, this approach requires genotyping of thousands of genetic markers in large samples. In addition, a detailed analysis of the genes, expression of which changes under the influence of environmental factors, can indicate good candidates for genetic association studies. In this connection, investigations of the epigenetic regulation of genes and not only the DNA sequence variation, may be necessary for complete understanding of the etiopathogenic mechanisms of SCZ." @default.
• W2041406567 created "2016-06-24" @default.
• W2041406567 creator A5052373411 @default.
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• W2041406567 creator A5070460587 @default.
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• W2041406567 date "2002-08-01" @default.
• W2041406567 modified "2023-10-08" @default.
• W2041406567 title "Molecular genetic studies of schizophrenia: challenges and insights" @default.
• W2041406567 cites W1486257535 @default.
• W2041406567 cites W1489653248 @default.
• W2041406567 cites W1545695267 @default.
• W2041406567 cites W1566810616 @default.
• W2041406567 cites W1583476286 @default.
• W2041406567 cites W1784857457 @default.
• W2041406567 cites W1843168095 @default.
• W2041406567 cites W1963936426 @default.
• W2041406567 cites W1964007647 @default.
• W2041406567 cites W1964767369 @default.
• W2041406567 cites W1965871695 @default.
• W2041406567 cites W1967036667 @default.
• W2041406567 cites W1967481121 @default.
• W2041406567 cites W1970737542 @default.
• W2041406567 cites W1970967627 @default.
• W2041406567 cites W1973913815 @default.
• W2041406567 cites W1976741643 @default.
• W2041406567 cites W1978194766 @default.
• W2041406567 cites W1978413536 @default.
• W2041406567 cites W1978654280 @default.
• W2041406567 cites W1979261166 @default.
• W2041406567 cites W1982661591 @default.
• W2041406567 cites W1982806869 @default.
• W2041406567 cites W1985994929 @default.
• W2041406567 cites W1991820785 @default.
• W2041406567 cites W1991872893 @default.
• W2041406567 cites W1993206740 @default.
• W2041406567 cites W1994147836 @default.
• W2041406567 cites W1997494071 @default.
• W2041406567 cites W1998392951 @default.
• W2041406567 cites W2004354911 @default.
• W2041406567 cites W2008047653 @default.
• W2041406567 cites W2008461666 @default.
• W2041406567 cites W2010796708 @default.
• W2041406567 cites W2012768252 @default.
• W2041406567 cites W2015744086 @default.
• W2041406567 cites W2015908820 @default.
• W2041406567 cites W2015951593 @default.
• W2041406567 cites W2021339638 @default.
• W2041406567 cites W2021357264 @default.
• W2041406567 cites W2024054703 @default.
• W2041406567 cites W2025497083 @default.
• W2041406567 cites W2026242583 @default.
• W2041406567 cites W2034008819 @default.
• W2041406567 cites W2037379301 @default.
• W2041406567 cites W2039440352 @default.
• W2041406567 cites W2040214825 @default.
• W2041406567 cites W2041120655 @default.
• W2041406567 cites W2041137556 @default.
• W2041406567 cites W2042103448 @default.
• W2041406567 cites W2042823677 @default.
• W2041406567 cites W2045564624 @default.
• W2041406567 cites W2046505883 @default.
• W2041406567 cites W2049264450 @default.
• W2041406567 cites W2049414355 @default.
• W2041406567 cites W2051420506 @default.
• W2041406567 cites W2051883032 @default.
• W2041406567 cites W2052536256 @default.
• W2041406567 cites W2052713474 @default.
• W2041406567 cites W2055140345 @default.
• W2041406567 cites W2056866499 @default.
• W2041406567 cites W2060716089 @default.
• W2041406567 cites W2064510510 @default.
• W2041406567 cites W2065830684 @default.
• W2041406567 cites W2065990925 @default.
• W2041406567 cites W2067723059 @default.
• W2041406567 cites W2069169238 @default.
• W2041406567 cites W2070303582 @default.
• W2041406567 cites W2070327659 @default.
• W2041406567 cites W2070564733 @default.
• W2041406567 cites W2072964995 @default.
• W2041406567 cites W2073001950 @default.
• W2041406567 cites W2080167581 @default.
• W2041406567 cites W2081790533 @default.
• W2041406567 cites W2082656717 @default.
• W2041406567 cites W2084098888 @default.
• W2041406567 cites W2089380329 @default.
• W2041406567 cites W2090341988 @default.
• W2041406567 cites W2091951581 @default.
• W2041406567 cites W2092947663 @default.
• W2041406567 cites W2093546390 @default.
• W2041406567 cites W2099722464 @default.
• W2041406567 cites W2105097410 @default.
• W2041406567 cites W2105789105 @default.
• W2041406567 cites W2107470795 @default.
• W2041406567 cites W2107515797 @default.
• W2041406567 cites W2116708238 @default.

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