FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041408924> ?p ?o ?g. }

• W2041408924 abstract "The receptor for the cardiac hormone atrial natriuretic peptide (ANP), natriuretic peptide receptor A (NPRA), is expressed in cancer cells, and natriuretic peptides have been implicated in cancers. However, the direct role of NPRA signaling in prostate cancer remains unclear.NPRA expression was examined by western blotting, RT-PCR and immunohistochemistry. NPRA was downregulated by transfection of siRNA, shRNA and NPRA inhibitor (iNPRA). Antitumor efficacy of iNPRA was tested in mice using a TRAMP-C1 xenograft. Here, we demonstrated that NPRA is abundantly expressed on tumorigenic mouse and human prostate cells, but not in nontumorigenic prostate epithelial cells. NPRA expression showed positive correlation with clinical staging in a human PCa tissue microarray. Down-regulation of NPRA by siNPRA or iNPRA induced apoptosis in PCa cells. The mechanism of iNPRA-induced anti-PCa effects was linked to NPRA-induced expression of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine over-expressed in PCa and significantly reduced by siNPRA. Prostate tumor cells implanted in mice deficient in atrial natriuretic peptide receptor A (NPRA-KO) failed to grow, and treatment of TRAMP-C1 xenografts with iNPRA reduced tumor burden and MIF expression. Using the TRAMP spontaneous PCa model, we found that NPRA expression correlated with MIF expression during PCa progression.Collectively, these results suggest that NPRA promotes PCa development in part by regulating MIF. Our findings also suggest that NPRA is a potential prognostic marker and a target for PCa therapy." @default.
• W2041408924 created "2016-06-24" @default.
• W2041408924 creator A5010321945 @default.
• W2041408924 creator A5020993698 @default.
• W2041408924 creator A5023344713 @default.
• W2041408924 creator A5031611765 @default.
• W2041408924 creator A5036205730 @default.
• W2041408924 creator A5053676002 @default.
• W2041408924 creator A5057680842 @default.
• W2041408924 creator A5076324164 @default.
• W2041408924 creator A5085124801 @default.
• W2041408924 creator A5089465392 @default.
• W2041408924 date "2011-05-17" @default.
• W2041408924 modified "2023-10-15" @default.
• W2041408924 title "Natriuretic Peptide Receptor A as a Novel Target for Prostate Cancer" @default.
• W2041408924 cites W1542858039 @default.
• W2041408924 cites W1687951909 @default.
• W2041408924 cites W1815183856 @default.
• W2041408924 cites W1970094818 @default.
• W2041408924 cites W1970855927 @default.
• W2041408924 cites W1979097970 @default.
• W2041408924 cites W1981047060 @default.
• W2041408924 cites W1992767594 @default.
• W2041408924 cites W2000961343 @default.
• W2041408924 cites W2011341848 @default.
• W2041408924 cites W2014431983 @default.
• W2041408924 cites W2014960791 @default.
• W2041408924 cites W2018982924 @default.
• W2041408924 cites W2020719670 @default.
• W2041408924 cites W2029741892 @default.
• W2041408924 cites W2039316329 @default.
• W2041408924 cites W2040943550 @default.
• W2041408924 cites W2054281553 @default.
• W2041408924 cites W2059724367 @default.
• W2041408924 cites W2061466636 @default.
• W2041408924 cites W2064200041 @default.
• W2041408924 cites W2064418518 @default.
• W2041408924 cites W2075253457 @default.
• W2041408924 cites W2084642119 @default.
• W2041408924 cites W2085341087 @default.
• W2041408924 cites W2089415167 @default.
• W2041408924 cites W2091633379 @default.
• W2041408924 cites W2092716271 @default.
• W2041408924 cites W2093695309 @default.
• W2041408924 cites W2103004412 @default.
• W2041408924 cites W2114358919 @default.
• W2041408924 cites W2118142096 @default.
• W2041408924 cites W2119005477 @default.
• W2041408924 cites W2123857513 @default.
• W2041408924 cites W2127830663 @default.
• W2041408924 cites W2128096753 @default.
• W2041408924 cites W2132168200 @default.
• W2041408924 cites W2149044230 @default.
• W2041408924 cites W2151324279 @default.
• W2041408924 cites W2156272715 @default.
• W2041408924 doi "https://doi.org/10.1186/1476-4598-10-56" @default.
• W2041408924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3121714" @default.
• W2041408924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21586128" @default.
• W2041408924 hasPublicationYear "2011" @default.
• W2041408924 type Work @default.
• W2041408924 sameAs 2041408924 @default.
• W2041408924 citedByCount "28" @default.
• W2041408924 countsByYear W20414089242012 @default.
• W2041408924 countsByYear W20414089242013 @default.
• W2041408924 countsByYear W20414089242014 @default.
• W2041408924 countsByYear W20414089242015 @default.
• W2041408924 countsByYear W20414089242016 @default.
• W2041408924 countsByYear W20414089242017 @default.
• W2041408924 countsByYear W20414089242018 @default.
• W2041408924 countsByYear W20414089242019 @default.
• W2041408924 countsByYear W20414089242020 @default.
• W2041408924 countsByYear W20414089242021 @default.
• W2041408924 crossrefType "journal-article" @default.
• W2041408924 hasAuthorship W2041408924A5010321945 @default.
• W2041408924 hasAuthorship W2041408924A5020993698 @default.
• W2041408924 hasAuthorship W2041408924A5023344713 @default.
• W2041408924 hasAuthorship W2041408924A5031611765 @default.
• W2041408924 hasAuthorship W2041408924A5036205730 @default.
• W2041408924 hasAuthorship W2041408924A5053676002 @default.
• W2041408924 hasAuthorship W2041408924A5057680842 @default.
• W2041408924 hasAuthorship W2041408924A5076324164 @default.
• W2041408924 hasAuthorship W2041408924A5085124801 @default.
• W2041408924 hasAuthorship W2041408924A5089465392 @default.
• W2041408924 hasBestOaLocation W20414089241 @default.
• W2041408924 hasConcept C104177226 @default.
• W2041408924 hasConcept C121608353 @default.
• W2041408924 hasConcept C126322002 @default.
• W2041408924 hasConcept C134018914 @default.
• W2041408924 hasConcept C170493617 @default.
• W2041408924 hasConcept C2775915353 @default.
• W2041408924 hasConcept C2776235491 @default.
• W2041408924 hasConcept C2778069365 @default.
• W2041408924 hasConcept C2778198053 @default.
• W2041408924 hasConcept C2778690821 @default.
• W2041408924 hasConcept C2780192828 @default.
• W2041408924 hasConcept C502942594 @default.
• W2041408924 hasConcept C71924100 @default.
• W2041408924 hasConcept C86803240 @default.
• W2041408924 hasConceptScore W2041408924C104177226 @default.
• W2041408924 hasConceptScore W2041408924C121608353 @default.

• next