Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041414577> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2041414577 endingPage "298" @default.
- W2041414577 startingPage "298" @default.
- W2041414577 abstract "Helicobacter pylori lipid A, characterised by a glucosamine β(1–6) disaccharide 1-(2-aminoethyl)phosphate acylated by (R)-3-hydroxyoctadecanoic acid and (R)-3-(octadecanoyloxy)octadecanoic acid at the 2- and 2′-positions, respectively, exhibited no or very low endotoxic activities, i.e. lethal toxicity in galactosamine-loaded mice, pyrogenicity for rabbits and the activity of the Limulus test compared with Escherichia coli-type synthetic lipid A (compound 506), which possesses β-(1–6)-linked glucosamine disaccharide 1,4′-bisphosphate, with two acyloxyacyl groups at the 2′- and 3′-positions and two 3-hydroxytetradecanoyl groups at the 2- and 3-positions. The endotoxic properties of H. pylori lipid A were also a little weaker than those of the low endotoxic lipid A of P. gingivalis, which has 1-phospho β-(1–6)-linked glucosamine disaccharide with 3-hydroxy-15-methylhexadecanoyl and 3-hexadecanoyloxy-15-methylhexadecanoyl groups at the 2- and 2′-positions, respectively. Further, the mitogenic activity of H. pylori lipid A in murine splenic mononuclear cells was also less than those of P. gingivalis lipid A and compound 506. However, H. pylori lipid A induced comparable production of interleukin-6 (IL-6) by human peripheral blood mononuclear cells (PBMC) compared with P. gingivalis lipid A and compound 506. H. pylori lipid A also increased human natural killer cell activity, and strongly agglutinated rabbit erythrocytes. However, the lipid As of H. pylori and P. gingivalis showed lower activities in inducing tumour necrosis factor alpha (TNF-α) production by human PBMC and IL-8 production by human gingival fibroblasts than that of compound 506. The structural feature of H. pylori lipid A may be associated with low endotoxic properties and potent immunobiological activities." @default.
- W2041414577 created "2016-06-24" @default.
- W2041414577 creator A5007754695 @default.
- W2041414577 creator A5011261080 @default.
- W2041414577 creator A5023848692 @default.
- W2041414577 creator A5030015659 @default.
- W2041414577 creator A5042815651 @default.
- W2041414577 date "1985-01-01" @default.
- W2041414577 modified "2023-10-18" @default.
- W2041414577 title "NK cells stimulating properties of a non capsulated klebsiella pneumoniae biotype A membranal proteoglycan" @default.
- W2041414577 doi "https://doi.org/10.1016/0192-0561(85)90173-0" @default.
- W2041414577 hasPublicationYear "1985" @default.
- W2041414577 type Work @default.
- W2041414577 sameAs 2041414577 @default.
- W2041414577 citedByCount "1" @default.
- W2041414577 crossrefType "journal-article" @default.
- W2041414577 hasAuthorship W2041414577A5007754695 @default.
- W2041414577 hasAuthorship W2041414577A5011261080 @default.
- W2041414577 hasAuthorship W2041414577A5023848692 @default.
- W2041414577 hasAuthorship W2041414577A5030015659 @default.
- W2041414577 hasAuthorship W2041414577A5042815651 @default.
- W2041414577 hasConcept C137061746 @default.
- W2041414577 hasConcept C144464004 @default.
- W2041414577 hasConcept C151730666 @default.
- W2041414577 hasConcept C185592680 @default.
- W2041414577 hasConcept C202751555 @default.
- W2041414577 hasConcept C203014093 @default.
- W2041414577 hasConcept C22222904 @default.
- W2041414577 hasConcept C2776487282 @default.
- W2041414577 hasConcept C2777346074 @default.
- W2041414577 hasConcept C2778125326 @default.
- W2041414577 hasConcept C2778754761 @default.
- W2041414577 hasConcept C55493867 @default.
- W2041414577 hasConcept C86803240 @default.
- W2041414577 hasConcept C89423630 @default.
- W2041414577 hasConceptScore W2041414577C137061746 @default.
- W2041414577 hasConceptScore W2041414577C144464004 @default.
- W2041414577 hasConceptScore W2041414577C151730666 @default.
- W2041414577 hasConceptScore W2041414577C185592680 @default.
- W2041414577 hasConceptScore W2041414577C202751555 @default.
- W2041414577 hasConceptScore W2041414577C203014093 @default.
- W2041414577 hasConceptScore W2041414577C22222904 @default.
- W2041414577 hasConceptScore W2041414577C2776487282 @default.
- W2041414577 hasConceptScore W2041414577C2777346074 @default.
- W2041414577 hasConceptScore W2041414577C2778125326 @default.
- W2041414577 hasConceptScore W2041414577C2778754761 @default.
- W2041414577 hasConceptScore W2041414577C55493867 @default.
- W2041414577 hasConceptScore W2041414577C86803240 @default.
- W2041414577 hasConceptScore W2041414577C89423630 @default.
- W2041414577 hasIssue "3" @default.
- W2041414577 hasLocation W20414145771 @default.
- W2041414577 hasOpenAccess W2041414577 @default.
- W2041414577 hasPrimaryLocation W20414145771 @default.
- W2041414577 hasRelatedWork W133046155 @default.
- W2041414577 hasRelatedWork W1521437477 @default.
- W2041414577 hasRelatedWork W1969862276 @default.
- W2041414577 hasRelatedWork W1997223193 @default.
- W2041414577 hasRelatedWork W2010461721 @default.
- W2041414577 hasRelatedWork W2033076661 @default.
- W2041414577 hasRelatedWork W2136540250 @default.
- W2041414577 hasRelatedWork W2158412618 @default.
- W2041414577 hasRelatedWork W2313849458 @default.
- W2041414577 hasRelatedWork W3033208992 @default.
- W2041414577 hasVolume "7" @default.
- W2041414577 isParatext "false" @default.
- W2041414577 isRetracted "false" @default.
- W2041414577 magId "2041414577" @default.
- W2041414577 workType "article" @default.