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• W2041416907 abstract "The prenatal effects of methotrexate (MTX) in rats and rabbits were assessed. It was found highly embryotoxic in postimplantation rat embryos; 0.3 mg/kg ip or less caused nearly total embryolethality with slight teratogenicity. Rabbit embryos were far more resistant to small doses of MTX than rats, but 19.2 mg/kg iv, when given during days 10 to 15 of gestation, produced little death and a constant spectrum of malformation in a high percentage of offspring. Cleft palate, skull defects, and severe fore-and hindlimb dysplasias, occurred with a high degree of regularity and were strongly dose and developmental-stage specific." @default.
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• W2041416907 date "1977-02-01" @default.
• W2041416907 modified "2023-10-16" @default.
• W2041416907 title "Embryotoxicity of the folate antagonist methotrexate in rats and rabbits" @default.
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• W2041416907 doi "https://doi.org/10.1002/tera.1420150110" @default.
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