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• W2041420264 abstract "In a group of four human tumor cell lines comprising one melanoma, one glioma, one teratocarcinoma and one neuroblastoma, the expression of the intercellular adhesion molecule-1 (ICAM-1) was found to be significantly increased following treatment with 10 μM of all-trans retinoic acid. In the melanoma and glioma cell lines HS 294T and HS 683, > 90% of the cells reacted with the anti-ICAM-1 monoclonal antibody (mAb) CL203.4 in the absence of treatment. Retinoic acid increased the cell surface expression of the molecule by 2-fold. In the teratocarcinoma and neuroblastoma cell lines, TERA-2 and SK-N-SH, the constitutive expression of ICAM-1 was weak, the percentage of cells stained above the background being <25%. Retinoic acid induced ICAM-1 exression in >80% of the cells and increased the levels of expression bu 2.5 to 3-fold. Immunoprecipitation studies in biosynthetically labeled cells as well as RNase protection analysis confirmed that retinoic acid treatment increased the amount of ICAM-1 at both the protein and mRNA level. The induction or stimulation occured within 24 h, was maximal after 4 days and reversible." @default.
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• W2041420264 date "1991-09-01" @default.
• W2041420264 modified "2023-09-29" @default.
• W2041420264 title "Regulation by retinoic acid of ICAM-1 expression on human tumor cell lines" @default.
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• W2041420264 doi "https://doi.org/10.1016/0925-4439(91)90091-m" @default.
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