FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041423909> ?p ?o ?g. }

• W2041423909 endingPage "384" @default.
• W2041423909 startingPage "373" @default.
• W2041423909 abstract "Sprague-Dawley (SD) rats are broadly used in preclinical studies for drug development, so a lot of information for the rats can be obtained especially from pharmacokinetic, pharmacological and toxicological studies. The purpose of this study was to clarify whether SD rat skin can be used to predict human skin permeability. In vitro permeation studies of the three model drugs, nicorandil, isosorbide dinitrate, and flurbiprofen, through human skin and SD rat skin were performed using Franz-type diffusion cells. The permeation rates of the three model drugs through human skin and SD rat skin were determined, and their variations were evaluated. The inter-individual variations in SD rat skin permeability of the three model drugs were much lower than that in human skin permeability, although the permeation rates of the three model drugs through the SD rat skin were about twice those through human skin. In addition, no difference in the skin permeability coefficients of the three model drugs was obtained between fresh SD rat skin and frozen SD rat skin. The markedly smaller variation in the permeability through SD rat skin compared with that through human skin indicated that in vitro permeation studies using SD rat skin would be especially useful for evaluating differences in the skin permeability of the three model drugs as well as for predicting human skin permeability." @default.
• W2041423909 created "2016-06-24" @default.
• W2041423909 creator A5006446842 @default.
• W2041423909 creator A5029228118 @default.
• W2041423909 creator A5052992512 @default.
• W2041423909 creator A5067817332 @default.
• W2041423909 creator A5076616409 @default.
• W2041423909 creator A5086954727 @default.
• W2041423909 creator A5088483233 @default.
• W2041423909 date "2011-01-01" @default.
• W2041423909 modified "2023-09-26" @default.
• W2041423909 title "Usefulness of Rat Skin as a Substitute for Human Skin in the in Vitro Skin Permeation Study" @default.
• W2041423909 cites W1210654754 @default.
• W2041423909 cites W1963875977 @default.
• W2041423909 cites W1984858903 @default.
• W2041423909 cites W1989548178 @default.
• W2041423909 cites W1999640716 @default.
• W2041423909 cites W2000574141 @default.
• W2041423909 cites W2003735503 @default.
• W2041423909 cites W2023374102 @default.
• W2041423909 cites W2025190015 @default.
• W2041423909 cites W2026709799 @default.
• W2041423909 cites W2036815885 @default.
• W2041423909 cites W2036825753 @default.
• W2041423909 cites W2045800643 @default.
• W2041423909 cites W2053190965 @default.
• W2041423909 cites W2058520508 @default.
• W2041423909 cites W2059196910 @default.
• W2041423909 cites W2060929621 @default.
• W2041423909 cites W2063229676 @default.
• W2041423909 cites W2078936639 @default.
• W2041423909 cites W2081534467 @default.
• W2041423909 cites W2084294282 @default.
• W2041423909 cites W2086139738 @default.
• W2041423909 cites W2089229095 @default.
• W2041423909 cites W2091247610 @default.
• W2041423909 cites W2095067107 @default.
• W2041423909 cites W2101453828 @default.
• W2041423909 cites W2138556058 @default.
• W2041423909 cites W2162845988 @default.
• W2041423909 cites W2170139938 @default.
• W2041423909 cites W4238245781 @default.
• W2041423909 doi "https://doi.org/10.1538/expanim.60.373" @default.
• W2041423909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21791877" @default.
• W2041423909 hasPublicationYear "2011" @default.
• W2041423909 type Work @default.
• W2041423909 sameAs 2041423909 @default.
• W2041423909 citedByCount "73" @default.
• W2041423909 countsByYear W20414239092012 @default.
• W2041423909 countsByYear W20414239092013 @default.
• W2041423909 countsByYear W20414239092014 @default.
• W2041423909 countsByYear W20414239092015 @default.
• W2041423909 countsByYear W20414239092016 @default.
• W2041423909 countsByYear W20414239092017 @default.
• W2041423909 countsByYear W20414239092018 @default.
• W2041423909 countsByYear W20414239092019 @default.
• W2041423909 countsByYear W20414239092020 @default.
• W2041423909 countsByYear W20414239092021 @default.
• W2041423909 countsByYear W20414239092022 @default.
• W2041423909 countsByYear W20414239092023 @default.
• W2041423909 crossrefType "journal-article" @default.
• W2041423909 hasAuthorship W2041423909A5006446842 @default.
• W2041423909 hasAuthorship W2041423909A5029228118 @default.
• W2041423909 hasAuthorship W2041423909A5052992512 @default.
• W2041423909 hasAuthorship W2041423909A5067817332 @default.
• W2041423909 hasAuthorship W2041423909A5076616409 @default.
• W2041423909 hasAuthorship W2041423909A5086954727 @default.
• W2041423909 hasAuthorship W2041423909A5088483233 @default.
• W2041423909 hasBestOaLocation W20414239091 @default.
• W2041423909 hasConcept C120882062 @default.
• W2041423909 hasConcept C126322002 @default.
• W2041423909 hasConcept C185592680 @default.
• W2041423909 hasConcept C202751555 @default.
• W2041423909 hasConcept C2776391296 @default.
• W2041423909 hasConcept C2777074287 @default.
• W2041423909 hasConcept C2777459323 @default.
• W2041423909 hasConcept C2778949068 @default.
• W2041423909 hasConcept C2780035454 @default.
• W2041423909 hasConcept C41625074 @default.
• W2041423909 hasConcept C50670333 @default.
• W2041423909 hasConcept C54355233 @default.
• W2041423909 hasConcept C55493867 @default.
• W2041423909 hasConcept C71924100 @default.
• W2041423909 hasConcept C86803240 @default.
• W2041423909 hasConcept C98274493 @default.
• W2041423909 hasConceptScore W2041423909C120882062 @default.
• W2041423909 hasConceptScore W2041423909C126322002 @default.
• W2041423909 hasConceptScore W2041423909C185592680 @default.
• W2041423909 hasConceptScore W2041423909C202751555 @default.
• W2041423909 hasConceptScore W2041423909C2776391296 @default.
• W2041423909 hasConceptScore W2041423909C2777074287 @default.
• W2041423909 hasConceptScore W2041423909C2777459323 @default.
• W2041423909 hasConceptScore W2041423909C2778949068 @default.
• W2041423909 hasConceptScore W2041423909C2780035454 @default.
• W2041423909 hasConceptScore W2041423909C41625074 @default.
• W2041423909 hasConceptScore W2041423909C50670333 @default.
• W2041423909 hasConceptScore W2041423909C54355233 @default.
• W2041423909 hasConceptScore W2041423909C55493867 @default.

• next