Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041435741> ?p ?o ?g. }
- W2041435741 endingPage "300" @default.
- W2041435741 startingPage "292" @default.
- W2041435741 abstract "We performed an unbiased experimental search for enhancers and silencers in a 153-kb region containing the human apolipoprotein (APO) E/C1/C4/C2 gene cluster using shotgun cloning into a luciferase vector. A continuum of transcriptional effect sizes was observed, possibly explaining the limited success of bioinformatics in identifying regulatory regions. We identified nine statistically significant enhancers and five silencers functional in either liver or astrocyte cells, including two previously known enhancers. Only two of the fourteen elements contained conserved noncoding sequences. Within the coding sequence of the APOE gene we identified an enhancer for the E4 allele associated with Alzheimer's disease, but not E3. The single nucleotide polymorphism (SNP) causing the E4/E3 amino acid substitution was responsible for these variations, potentially explaining the higher expression levels of E4. Our results suggest a wider variety of mammalian transcriptional regulatory sequences than is currently recognized and that these may include coding region SNPs." @default.
- W2041435741 created "2016-06-24" @default.
- W2041435741 creator A5009399875 @default.
- W2041435741 creator A5037983975 @default.
- W2041435741 creator A5051619512 @default.
- W2041435741 creator A5053750606 @default.
- W2041435741 creator A5076886504 @default.
- W2041435741 creator A5083189787 @default.
- W2041435741 date "2008-11-01" @default.
- W2041435741 modified "2023-10-03" @default.
- W2041435741 title "Screening reveals conserved and nonconserved transcriptional regulatory elements including an E3/E4 allele-dependent APOE coding region enhancer" @default.
- W2041435741 cites W1480240286 @default.
- W2041435741 cites W1483073028 @default.
- W2041435741 cites W1485381771 @default.
- W2041435741 cites W1912127524 @default.
- W2041435741 cites W1969770714 @default.
- W2041435741 cites W1977416347 @default.
- W2041435741 cites W1983430442 @default.
- W2041435741 cites W1993741978 @default.
- W2041435741 cites W1996760543 @default.
- W2041435741 cites W1999631936 @default.
- W2041435741 cites W2022756254 @default.
- W2041435741 cites W2025665146 @default.
- W2041435741 cites W2026652568 @default.
- W2041435741 cites W2029873987 @default.
- W2041435741 cites W2039923266 @default.
- W2041435741 cites W2052647271 @default.
- W2041435741 cites W2055043387 @default.
- W2041435741 cites W2063125022 @default.
- W2041435741 cites W2079842264 @default.
- W2041435741 cites W2080604150 @default.
- W2041435741 cites W2081998831 @default.
- W2041435741 cites W2084620487 @default.
- W2041435741 cites W2094036688 @default.
- W2041435741 cites W2100990361 @default.
- W2041435741 cites W2102304447 @default.
- W2041435741 cites W2107680694 @default.
- W2041435741 cites W2107828904 @default.
- W2041435741 cites W2117549173 @default.
- W2041435741 cites W2140538490 @default.
- W2041435741 cites W2145191876 @default.
- W2041435741 cites W2150802827 @default.
- W2041435741 cites W2152192643 @default.
- W2041435741 cites W2159164310 @default.
- W2041435741 cites W2161711244 @default.
- W2041435741 cites W2169359444 @default.
- W2041435741 cites W4233622592 @default.
- W2041435741 cites W4254753097 @default.
- W2041435741 doi "https://doi.org/10.1016/j.ygeno.2008.07.009" @default.
- W2041435741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18718521" @default.
- W2041435741 hasPublicationYear "2008" @default.
- W2041435741 type Work @default.
- W2041435741 sameAs 2041435741 @default.
- W2041435741 citedByCount "17" @default.
- W2041435741 countsByYear W20414357412012 @default.
- W2041435741 countsByYear W20414357412013 @default.
- W2041435741 countsByYear W20414357412015 @default.
- W2041435741 countsByYear W20414357412017 @default.
- W2041435741 countsByYear W20414357412021 @default.
- W2041435741 countsByYear W20414357412022 @default.
- W2041435741 countsByYear W20414357412023 @default.
- W2041435741 crossrefType "journal-article" @default.
- W2041435741 hasAuthorship W2041435741A5009399875 @default.
- W2041435741 hasAuthorship W2041435741A5037983975 @default.
- W2041435741 hasAuthorship W2041435741A5051619512 @default.
- W2041435741 hasAuthorship W2041435741A5053750606 @default.
- W2041435741 hasAuthorship W2041435741A5076886504 @default.
- W2041435741 hasAuthorship W2041435741A5083189787 @default.
- W2041435741 hasConcept C104317684 @default.
- W2041435741 hasConcept C111936080 @default.
- W2041435741 hasConcept C135763542 @default.
- W2041435741 hasConcept C150194340 @default.
- W2041435741 hasConcept C153209595 @default.
- W2041435741 hasConcept C165864922 @default.
- W2041435741 hasConcept C180754005 @default.
- W2041435741 hasConcept C21592294 @default.
- W2041435741 hasConcept C41091548 @default.
- W2041435741 hasConcept C54355233 @default.
- W2041435741 hasConcept C86803240 @default.
- W2041435741 hasConcept C91779695 @default.
- W2041435741 hasConceptScore W2041435741C104317684 @default.
- W2041435741 hasConceptScore W2041435741C111936080 @default.
- W2041435741 hasConceptScore W2041435741C135763542 @default.
- W2041435741 hasConceptScore W2041435741C150194340 @default.
- W2041435741 hasConceptScore W2041435741C153209595 @default.
- W2041435741 hasConceptScore W2041435741C165864922 @default.
- W2041435741 hasConceptScore W2041435741C180754005 @default.
- W2041435741 hasConceptScore W2041435741C21592294 @default.
- W2041435741 hasConceptScore W2041435741C41091548 @default.
- W2041435741 hasConceptScore W2041435741C54355233 @default.
- W2041435741 hasConceptScore W2041435741C86803240 @default.
- W2041435741 hasConceptScore W2041435741C91779695 @default.
- W2041435741 hasIssue "5" @default.
- W2041435741 hasLocation W20414357411 @default.
- W2041435741 hasLocation W20414357412 @default.
- W2041435741 hasOpenAccess W2041435741 @default.
- W2041435741 hasPrimaryLocation W20414357411 @default.
- W2041435741 hasRelatedWork W1970327593 @default.