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- W2041439040 abstract "The mGluR1 metabotropic glutamate receptor is a G-protein-coupled receptor that exists as different C-terminal splice variants. When expressed in mammalian cells, the mGluR1 splice variants exhibit diverse transduction mechanisms and also slightly differ in their apparent agonist affinities. In the present study, we used an affinity-purified antiserum, specifically reactive to the mGluR1b splice variant, in combination with a highly sensitive preembedding immunocytochemical method for light microscopy to investigate the distribution of this receptor in the rat hypothalamus. An intense immunoreactivity for mGluR1b was observed in distinct hypothalamic nuclei. Thus, neuronal cell bodies and dendrites were stained in the preoptic area, suprachiasmatic nucleus, dorsal hypothalamus, lateral hypothalamus, dorsomedial nucleus, tuberomammilary nucleus, and lateral mammilary body. The ventromedial nucleus exhibited neuropil immunostaining but neuronal cell bodies were not labeled. Strong mGluR1b immunoreactivity was observed in magnocellular neurons of the neuroendocrine supraoptic, paraventricular, and arcuate nuclei. Also, neuronal cell bodies were heavily labeled in the retrochiasmatic nucleus, anterior commissural nucleus, and periventricular nucleus. These immunocytochemical observations, together with previous studies, suggest that mGluR1b is coexpressed with other class I mGluRs in some nuclei throughout the hypothalamus. However, mGluR1b is so far the only receptor of this class strongly expressed in the supraoptic, paraventricular, and arcuate nuclei, which might have relevant implications in the physiological control of the neuroendocrine hypothalamic-pituitary system. J. Comp. Neurol. 390:225–233, 1998. © 1998 Wiley-Liss, Inc." @default.
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- W2041439040 date "1998-01-12" @default.
- W2041439040 modified "2023-09-29" @default.
- W2041439040 title "Immunocytochemical localization of the mGluR1b metabotropic glutamate receptor in the rat hypothalamus" @default.
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- W2041439040 doi "https://doi.org/10.1002/(sici)1096-9861(19980112)390:2<225::aid-cne5>3.0.co;2-3" @default.
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