Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041442009> ?p ?o ?g. }
- W2041442009 endingPage "413" @default.
- W2041442009 startingPage "405" @default.
- W2041442009 abstract "Purpose: To characterize the vitreous intrinsic proteoglycans, investigate their dynamics, and examine their role in the supramolecular organization of the vitreous. Methods: Vitreous from normal rabbits was collected and processed for observation with the transmission electron microscope after treatment with glycosidases. Also, rabbits were injected intravitreally with [35S]-sodium sulfate and sacrificed at several time intervals after the injection. Proteoglycans (PGs) were assayed in the vitreous supernatant or in whole samples extracted with guanidine hydrochloride by polyacrylamide or agarose gel electrophoresis, followed respectively by fluorography or autoradiography, and ion-exchange chromatography and gel-filtration chromatography, combined with glycolytic treatment of the samples. The sulfated glycosaminoglycans (GAGs) were characterized by agarose gel electrophoresis after treating vitreous samples with protease and specific glycosidases. Results: The electron microscopic study revealed a network with hyaluronic acid (HA) as thin threads coating and connecting collagen fibrils. The elimination of the HA coat showed chondroitin sulfate granules (8–25 nm) arranged at regular intervals on the fibril surface. The chondroitinase ABC digestion, besides removing the granules, also caused the formation of thicker bundles of the collagen fibrils. The PG and GAG analysis indicated that there are three renewable PGs in the vitreous (e.g., one heparan- and two chondroitin-sulfate ones). Conclusions: At least one of the chondroitin sulfate PGs is involved in the interactions that occur in the vitreous structure, mainly by providing adequate spacing between the collagen fibrils, a condition that is probably required for the transparency of the vitreous." @default.
- W2041442009 created "2016-06-24" @default.
- W2041442009 creator A5004877137 @default.
- W2041442009 creator A5010388678 @default.
- W2041442009 creator A5024217499 @default.
- W2041442009 creator A5042522822 @default.
- W2041442009 creator A5087235862 @default.
- W2041442009 date "2005-01-01" @default.
- W2041442009 modified "2023-10-07" @default.
- W2041442009 title "Chondroitin Sulfate Proteoglycans Are Structural Renewable Constituents of the Rabbit Vitreous Body" @default.
- W2041442009 cites W1565114828 @default.
- W2041442009 cites W1567917359 @default.
- W2041442009 cites W1621137138 @default.
- W2041442009 cites W1658991581 @default.
- W2041442009 cites W1828237247 @default.
- W2041442009 cites W1966412926 @default.
- W2041442009 cites W1993827474 @default.
- W2041442009 cites W1996975390 @default.
- W2041442009 cites W1997924316 @default.
- W2041442009 cites W2000908347 @default.
- W2041442009 cites W2010681571 @default.
- W2041442009 cites W2021182217 @default.
- W2041442009 cites W2021455951 @default.
- W2041442009 cites W2024112688 @default.
- W2041442009 cites W2029551593 @default.
- W2041442009 cites W2029789899 @default.
- W2041442009 cites W2030482221 @default.
- W2041442009 cites W2033454869 @default.
- W2041442009 cites W2043990687 @default.
- W2041442009 cites W2050390676 @default.
- W2041442009 cites W2075950918 @default.
- W2041442009 cites W2086568512 @default.
- W2041442009 cites W2100837269 @default.
- W2041442009 cites W2133817791 @default.
- W2041442009 cites W2155080404 @default.
- W2041442009 cites W2165320222 @default.
- W2041442009 cites W2410848176 @default.
- W2041442009 cites W48361427 @default.
- W2041442009 cites W97587026 @default.
- W2041442009 doi "https://doi.org/10.1080/02713680590934148" @default.
- W2041442009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16020271" @default.
- W2041442009 hasPublicationYear "2005" @default.
- W2041442009 type Work @default.
- W2041442009 sameAs 2041442009 @default.
- W2041442009 citedByCount "20" @default.
- W2041442009 countsByYear W20414420092012 @default.
- W2041442009 countsByYear W20414420092014 @default.
- W2041442009 countsByYear W20414420092015 @default.
- W2041442009 countsByYear W20414420092016 @default.
- W2041442009 countsByYear W20414420092018 @default.
- W2041442009 countsByYear W20414420092019 @default.
- W2041442009 countsByYear W20414420092020 @default.
- W2041442009 countsByYear W20414420092021 @default.
- W2041442009 countsByYear W20414420092023 @default.
- W2041442009 crossrefType "journal-article" @default.
- W2041442009 hasAuthorship W2041442009A5004877137 @default.
- W2041442009 hasAuthorship W2041442009A5010388678 @default.
- W2041442009 hasAuthorship W2041442009A5024217499 @default.
- W2041442009 hasAuthorship W2041442009A5042522822 @default.
- W2041442009 hasAuthorship W2041442009A5087235862 @default.
- W2041442009 hasConcept C104317684 @default.
- W2041442009 hasConcept C153074725 @default.
- W2041442009 hasConcept C181199279 @default.
- W2041442009 hasConcept C185592680 @default.
- W2041442009 hasConcept C189165786 @default.
- W2041442009 hasConcept C193363816 @default.
- W2041442009 hasConcept C2776735749 @default.
- W2041442009 hasConcept C2778230131 @default.
- W2041442009 hasConcept C2778271344 @default.
- W2041442009 hasConcept C2778476535 @default.
- W2041442009 hasConcept C2779335624 @default.
- W2041442009 hasConcept C2779463914 @default.
- W2041442009 hasConcept C2779553658 @default.
- W2041442009 hasConcept C43617362 @default.
- W2041442009 hasConcept C55493867 @default.
- W2041442009 hasConceptScore W2041442009C104317684 @default.
- W2041442009 hasConceptScore W2041442009C153074725 @default.
- W2041442009 hasConceptScore W2041442009C181199279 @default.
- W2041442009 hasConceptScore W2041442009C185592680 @default.
- W2041442009 hasConceptScore W2041442009C189165786 @default.
- W2041442009 hasConceptScore W2041442009C193363816 @default.
- W2041442009 hasConceptScore W2041442009C2776735749 @default.
- W2041442009 hasConceptScore W2041442009C2778230131 @default.
- W2041442009 hasConceptScore W2041442009C2778271344 @default.
- W2041442009 hasConceptScore W2041442009C2778476535 @default.
- W2041442009 hasConceptScore W2041442009C2779335624 @default.
- W2041442009 hasConceptScore W2041442009C2779463914 @default.
- W2041442009 hasConceptScore W2041442009C2779553658 @default.
- W2041442009 hasConceptScore W2041442009C43617362 @default.
- W2041442009 hasConceptScore W2041442009C55493867 @default.
- W2041442009 hasIssue "5" @default.
- W2041442009 hasLocation W20414420091 @default.
- W2041442009 hasLocation W20414420092 @default.
- W2041442009 hasOpenAccess W2041442009 @default.
- W2041442009 hasPrimaryLocation W20414420091 @default.
- W2041442009 hasRelatedWork W1973120589 @default.
- W2041442009 hasRelatedWork W1978996455 @default.
- W2041442009 hasRelatedWork W1979251480 @default.