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- W2041445623 abstract "Degringolade (Dgrn) encodes a Drosophila SUMO-targeted ubiquitin ligase (STUbL) protein similar to that of mammalian RNF4. Dgrn facilitates the ubiquitylation of the HES protein Hairy, which disrupts the repressive activity of Hairy by inhibiting the recruitment of its cofactor Groucho. We show that Hey and all HES family members, except Her, interact with Dgrn and are substrates for its E3 ubiquitin ligase activity. Dgrn displays dynamic subcellular localization, accumulates in the nucleus at times when HES family members are active and limits Hey and HES family activity during sex determination, segmentation and neurogenesis. We show that Dgrn interacts with the Notch signaling pathway by it antagonizing the activity of E(spl)-C proteins. dgrn null mutants are female sterile, producing embryos that arrest development after two or three nuclear divisions. These mutant embryos exhibit fragmented or decondensed nuclei and accumulate higher levels of SUMO-conjugated proteins, suggesting a role for Dgrn in genome stability." @default.
- W2041445623 created "2016-06-24" @default.
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- W2041445623 date "2011-05-01" @default.
- W2041445623 modified "2023-10-10" @default.
- W2041445623 title "The<i>Drosophila</i>STUbL protein Degringolade limits HES functions during embryogenesis" @default.
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- W2041445623 cites W1987599413 @default.
- W2041445623 cites W1994218254 @default.
- W2041445623 cites W1996747646 @default.
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- W2041445623 cites W2000139612 @default.
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- W2041445623 doi "https://doi.org/10.1242/dev.058420" @default.
- W2041445623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3074452" @default.
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- W2041445623 hasPublicationYear "2011" @default.
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