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- W2041462215 abstract "Studies of the molecular biology of lymphoid cells have markedly increased our understanding of how millions of different antibodies can be synthesized by a single animal. To date, the most detailed understanding has been achieved for the mouse, primarily because of the relatively greater experimental availability of this species. These studies, as well as those involving other species, have shown that the complete genes for antibody polypeptide chains are assembled from disparate genetic elements which are originally widely separated in the genome. The assembly process itself, together with the coding information present in the germ line genetic elements, contributes to the diversity of structure (and thus combining specificities) shown by mature antibody molecules. Specifically, the diversity of structure characteristic of antibody variable regions is due to three distinct mechanisms: innate variability of germ line genes; mismatching of individual gene segments during their somatic rearrangement leading to junctional diversity; and somatic mutation in variable region genetic material during or after the rearrangement. These processes lead to the wide array of combining specificities that permit the humoral immune system of a mature animal to interact with essentially any non-self antigen which it encounters. Complex genetic rearrangements are also responsible for the class switching phenomenon long known to be characteristic of the humoral immune response. A form of homologous recombination between constant region genes, possibly mediated by specific switching enzymes, is now believed to be involved in this phenomenon. It is also currently believed that the restriction of gene rearrangement processes to one of the two possible chromosomes of a diploid pair in each cell is responsible for the phenomenon of allelic exclusion that has long been associated with the normal functioning of mammalian B-cells." @default.
- W2041462215 created "2016-06-24" @default.
- W2041462215 creator A5007832640 @default.
- W2041462215 creator A5066311140 @default.
- W2041462215 date "1983-03-01" @default.
- W2041462215 modified "2023-09-27" @default.
- W2041462215 title "The genetic control of antibody formation" @default.
- W2041462215 cites W1026356141 @default.
- W2041462215 cites W14557243 @default.
- W2041462215 cites W1510175790 @default.
- W2041462215 cites W1533561364 @default.
- W2041462215 cites W1572713517 @default.
- W2041462215 cites W1637798207 @default.
- W2041462215 cites W1737898466 @default.
- W2041462215 cites W1803870460 @default.
- W2041462215 cites W1963704405 @default.
- W2041462215 cites W1965084149 @default.
- W2041462215 cites W1966343066 @default.
- W2041462215 cites W1966481793 @default.
- W2041462215 cites W1968713887 @default.
- W2041462215 cites W1973099218 @default.
- W2041462215 cites W1974581377 @default.
- W2041462215 cites W1976291588 @default.
- W2041462215 cites W1977833662 @default.
- W2041462215 cites W1981042444 @default.
- W2041462215 cites W1982039072 @default.
- W2041462215 cites W1982305495 @default.
- W2041462215 cites W1984387553 @default.
- W2041462215 cites W1986038306 @default.
- W2041462215 cites W1989170328 @default.
- W2041462215 cites W1989172581 @default.
- W2041462215 cites W1989778243 @default.
- W2041462215 cites W1991172691 @default.
- W2041462215 cites W1992228474 @default.
- W2041462215 cites W1995378138 @default.
- W2041462215 cites W1999100206 @default.
- W2041462215 cites W2004707654 @default.
- W2041462215 cites W2005313969 @default.
- W2041462215 cites W2007643304 @default.
- W2041462215 cites W2007647936 @default.
- W2041462215 cites W2008200696 @default.
- W2041462215 cites W2009216293 @default.
- W2041462215 cites W2009792321 @default.
- W2041462215 cites W2012911917 @default.
- W2041462215 cites W2014435813 @default.
- W2041462215 cites W2017044557 @default.
- W2041462215 cites W2021097746 @default.
- W2041462215 cites W2021118214 @default.
- W2041462215 cites W2021465599 @default.
- W2041462215 cites W2022081448 @default.
- W2041462215 cites W2024859595 @default.
- W2041462215 cites W2027112152 @default.
- W2041462215 cites W2030558026 @default.
- W2041462215 cites W2037749628 @default.
- W2041462215 cites W2037969118 @default.
- W2041462215 cites W2038139201 @default.
- W2041462215 cites W2040199630 @default.
- W2041462215 cites W2040377419 @default.
- W2041462215 cites W2040647476 @default.
- W2041462215 cites W2040950236 @default.
- W2041462215 cites W2041217108 @default.
- W2041462215 cites W2049031211 @default.
- W2041462215 cites W2052472284 @default.
- W2041462215 cites W2054119564 @default.
- W2041462215 cites W2056680667 @default.
- W2041462215 cites W2057141478 @default.
- W2041462215 cites W2058809000 @default.
- W2041462215 cites W2059897736 @default.
- W2041462215 cites W2062193692 @default.
- W2041462215 cites W2063199192 @default.
- W2041462215 cites W2064421628 @default.
- W2041462215 cites W2068378281 @default.
- W2041462215 cites W2070855057 @default.
- W2041462215 cites W2070957765 @default.
- W2041462215 cites W2071186335 @default.
- W2041462215 cites W2075451170 @default.
- W2041462215 cites W2076856886 @default.
- W2041462215 cites W2081477822 @default.
- W2041462215 cites W2084877780 @default.
- W2041462215 cites W2085369521 @default.
- W2041462215 cites W2086789541 @default.
- W2041462215 cites W2088653018 @default.
- W2041462215 cites W2088984288 @default.
- W2041462215 cites W2091810736 @default.
- W2041462215 cites W2095230136 @default.
- W2041462215 cites W2098697357 @default.
- W2041462215 cites W2102635410 @default.
- W2041462215 cites W2137776746 @default.
- W2041462215 cites W2137911181 @default.
- W2041462215 cites W2141548731 @default.
- W2041462215 cites W2144628118 @default.
- W2041462215 cites W2146923243 @default.
- W2041462215 cites W2177431540 @default.
- W2041462215 cites W2312232267 @default.
- W2041462215 cites W2322120765 @default.
- W2041462215 cites W2327710116 @default.
- W2041462215 cites W2413108666 @default.
- W2041462215 cites W2501361427 @default.