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- W2041462341 abstract "The adhesion of a new Transdermal Therapeutic System (TTS) made of silicone and loaded with a progestomimetic drug was characterised. The goal of this study was to use well-known methods or to adapt them to collect representative data. Individually, methods such as surface tension, peel test and rheology are already widely used. Results show that the choice of a substrate for peel tests can be made in the light of surface tension data and that polymers like poly(tetrafluoroethylene) (PTFE) are good alternatives to skin. Peeling characterisations are made a function of thickness of films, drug content in active, conditions of preparation and conditions of use such as pressure. Dynamic rheology is more difficult to link to other methods as it mainly reflects internal phenomena and properties that arise in the bulk, as opposed on its surface. Master curves enable results to be used more easily, but the theories to interpret the data are still not powerful enough to replace peel testing." @default.
- W2041462341 created "2016-06-24" @default.
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- W2041462341 date "2000-04-10" @default.
- W2041462341 modified "2023-10-10" @default.
- W2041462341 title "Physical evaluation of a new patch made of a progestomimetic in a silicone matrix" @default.
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- W2041462341 doi "https://doi.org/10.1016/s0378-5173(00)00357-4" @default.
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