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• W2041474100 abstract "Described is a new method for the screening of an array of catalysts, in situ, to estimate enantioselectivity and relative rates. We term this approach double-cuvette ISES (in situ enzymatic screening). The Co(III)-salen mediated hydrolytic kinetic resolution (HKR) of (+/-)-propylene oxide is used as a model reaction to demonstrate proof of principle. In two parallel cuvettes, a lower CHCl3-based organic layer is loaded with the epoxide and the chiral salen catalyst. Aqueous reporting layers, containing distinct reporting enzymes and their nicotinamide cofactors, are layered above the organic layers. The 1,2-propanediol enantiomers formed by the chiral catalyst diffuse into the aqueous layer and are oxidized there by the reporting enzymes at rates dependent upon the diol concentration, the R:S ratio of the diol, and the enantioselectivity of the reporting enzymes. A focused chiral salen library was constructed from seven chiral 1,2-diamines, derived from amino acid, terpenoid, and carbohydrates skeletons, and seven salicylaldehyde derivatives. Double-cuvette ISES identified a couple of interesting combinatorial hits in this salen array, wherein either the sense or magnitude of enantioselection for a given chiral diamine depends significantly upon the choice of salicylaldehyde partner. A comparison of predicted ee's and relative rates using this new screening tool with those independently measured is provided." @default.
• W2041474100 created "2016-06-24" @default.
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• W2041474100 date "2005-05-26" @default.
• W2041474100 modified "2023-09-23" @default.
• W2041474100 title "Double-Cuvette ISES: In Situ Estimation of Enantioselectivity and Relative Rate for Catalyst Screening" @default.
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• W2041474100 doi "https://doi.org/10.1021/ja052010b" @default.
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