Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041480649> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2041480649 endingPage "387" @default.
- W2041480649 startingPage "385" @default.
- W2041480649 abstract "PAK1, a Rac/CDC42-dependent Ser/Thr kinase, is required for the malignant growth of RAS transformants as well as both NF1-deficient and NF2-deficient cancer cells. FK228, a histone deacetylase (HDAC) inhibitor, suppresses the growth of more than 70% of human cancers in vivo including RAS transformants, breast cancers and prostate cancers by activating a set of genes including the tumor suppressors gelsolin and p21(WAF1), that block upstream and downstream of PAK1, respectively. Here we demonstrate that (1) the anti-PAK1 drug FK228 (0.1 nM) completely blocks the growth of both NF1-deficient and NF2-deficient cancer cells in vitro, and that (2) FK228 (2.5 mg/kg, i.p., twice a week) causes the complete regression of an NF1-deficient human malignant peripheral nerve sheath tumor (MPNST) xenograft in nude mice. This is the very first case where a chemical drug in clinical trials for cancers has ever worked so effectively on neurofibromatosis (experimental neurofibromas) in vivo." @default.
- W2041480649 created "2016-06-24" @default.
- W2041480649 creator A5013519174 @default.
- W2041480649 creator A5022080735 @default.
- W2041480649 creator A5033017301 @default.
- W2041480649 creator A5035437527 @default.
- W2041480649 creator A5042615062 @default.
- W2041480649 creator A5045353364 @default.
- W2041480649 creator A5070999479 @default.
- W2041480649 date "2005-04-01" @default.
- W2041480649 modified "2023-10-17" @default.
- W2041480649 title "Signal therapy of NF1-deficient tumor xenograft in mice by the anti-PAK1 drug FK228" @default.
- W2041480649 doi "https://doi.org/10.4161/cbt.4.4.1649" @default.
- W2041480649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15846074" @default.
- W2041480649 hasPublicationYear "2005" @default.
- W2041480649 type Work @default.
- W2041480649 sameAs 2041480649 @default.
- W2041480649 citedByCount "32" @default.
- W2041480649 countsByYear W20414806492013 @default.
- W2041480649 countsByYear W20414806492014 @default.
- W2041480649 countsByYear W20414806492015 @default.
- W2041480649 countsByYear W20414806492017 @default.
- W2041480649 countsByYear W20414806492018 @default.
- W2041480649 countsByYear W20414806492019 @default.
- W2041480649 countsByYear W20414806492021 @default.
- W2041480649 countsByYear W20414806492022 @default.
- W2041480649 countsByYear W20414806492023 @default.
- W2041480649 crossrefType "journal-article" @default.
- W2041480649 hasAuthorship W2041480649A5013519174 @default.
- W2041480649 hasAuthorship W2041480649A5022080735 @default.
- W2041480649 hasAuthorship W2041480649A5033017301 @default.
- W2041480649 hasAuthorship W2041480649A5035437527 @default.
- W2041480649 hasAuthorship W2041480649A5042615062 @default.
- W2041480649 hasAuthorship W2041480649A5045353364 @default.
- W2041480649 hasAuthorship W2041480649A5070999479 @default.
- W2041480649 hasBestOaLocation W20414806491 @default.
- W2041480649 hasConcept C104317684 @default.
- W2041480649 hasConcept C150903083 @default.
- W2041480649 hasConcept C184235292 @default.
- W2041480649 hasConcept C207001950 @default.
- W2041480649 hasConcept C24901178 @default.
- W2041480649 hasConcept C2776202225 @default.
- W2041480649 hasConcept C2778305200 @default.
- W2041480649 hasConcept C502942594 @default.
- W2041480649 hasConcept C55493867 @default.
- W2041480649 hasConcept C64927066 @default.
- W2041480649 hasConcept C71924100 @default.
- W2041480649 hasConcept C86803240 @default.
- W2041480649 hasConcept C95444343 @default.
- W2041480649 hasConceptScore W2041480649C104317684 @default.
- W2041480649 hasConceptScore W2041480649C150903083 @default.
- W2041480649 hasConceptScore W2041480649C184235292 @default.
- W2041480649 hasConceptScore W2041480649C207001950 @default.
- W2041480649 hasConceptScore W2041480649C24901178 @default.
- W2041480649 hasConceptScore W2041480649C2776202225 @default.
- W2041480649 hasConceptScore W2041480649C2778305200 @default.
- W2041480649 hasConceptScore W2041480649C502942594 @default.
- W2041480649 hasConceptScore W2041480649C55493867 @default.
- W2041480649 hasConceptScore W2041480649C64927066 @default.
- W2041480649 hasConceptScore W2041480649C71924100 @default.
- W2041480649 hasConceptScore W2041480649C86803240 @default.
- W2041480649 hasConceptScore W2041480649C95444343 @default.
- W2041480649 hasIssue "4" @default.
- W2041480649 hasLocation W20414806491 @default.
- W2041480649 hasLocation W20414806492 @default.
- W2041480649 hasOpenAccess W2041480649 @default.
- W2041480649 hasPrimaryLocation W20414806491 @default.
- W2041480649 hasRelatedWork W1580990163 @default.
- W2041480649 hasRelatedWork W2029175848 @default.
- W2041480649 hasRelatedWork W2030301626 @default.
- W2041480649 hasRelatedWork W2033336929 @default.
- W2041480649 hasRelatedWork W2051615431 @default.
- W2041480649 hasRelatedWork W2074781740 @default.
- W2041480649 hasRelatedWork W2380287092 @default.
- W2041480649 hasRelatedWork W3029629975 @default.
- W2041480649 hasRelatedWork W3126958487 @default.
- W2041480649 hasRelatedWork W4361884305 @default.
- W2041480649 hasVolume "4" @default.
- W2041480649 isParatext "false" @default.
- W2041480649 isRetracted "false" @default.
- W2041480649 magId "2041480649" @default.
- W2041480649 workType "article" @default.