FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041485960> ?p ?o ?g. }

• W2041485960 endingPage "1601" @default.
• W2041485960 startingPage "1593" @default.
• W2041485960 abstract "Multiple genetic alterations are well recognized as contributing to pancreatic carcinogenesis, although the finding of recurrent copy number changes indicates additional targets remain to be found. The objective of this study was to identify novel targets of genetic alteration that contribute to pancreatic cancer development or progression. We used Representational Oligonucleotide Microarray Analysis (ROMA) to identify copy number changes in pancreatic cancer xenografts, and validated these findings using FISH, quantitative PCR, Western blotting and immunohistochemical labeling. With this approach, we identified a 0.36-Mb amplification at 18q11.2 containing two known genes, GATA-6 and cTAGE1. Using a cutoff value of 3.0 fold compared to haploid controls, copy number gain or amplification was confirmed in 4 of 42 (9.5%) pancreatic carcinomas analyzed. Combined genetic and transcriptional analyses showed consistent overexpression of GATA-6 in all carcinomas with 18q11.2 gain, as well as in the majority of pancreatic cancers examined (17 of 30 cancers, 56.7%) that did not have gain of this region. By contrast, overexpression of cTAGE1 was rare in these same cancers suggesting GATA-6 is the true target of this copy number increase. GATA-6 mRNA overexpression corresponded to robust nuclear protein expression in cancer cell lines and resected tissues consistent with its role as a transcription factor. Intense nuclear labeling was significantly increased in PanIN-3 lesions and infiltrating carcinomas compared to normal duct epithelium (p" @default.
• W2041485960 created "2016-06-24" @default.
• W2041485960 creator A5017260307 @default.
• W2041485960 creator A5033774772 @default.
• W2041485960 creator A5043757838 @default.
• W2041485960 creator A5077351183 @default.
• W2041485960 creator A5090743176 @default.
• W2041485960 date "2008-10-01" @default.
• W2041485960 modified "2023-10-15" @default.
• W2041485960 title "Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma" @default.
• W2041485960 cites W1517912342 @default.
• W2041485960 cites W1560979799 @default.
• W2041485960 cites W1604949025 @default.
• W2041485960 cites W1967656540 @default.
• W2041485960 cites W1970008083 @default.
• W2041485960 cites W1972366357 @default.
• W2041485960 cites W1974607289 @default.
• W2041485960 cites W2000420450 @default.
• W2041485960 cites W2015543753 @default.
• W2041485960 cites W2016631105 @default.
• W2041485960 cites W2036931975 @default.
• W2041485960 cites W2042386318 @default.
• W2041485960 cites W2042392104 @default.
• W2041485960 cites W2046163950 @default.
• W2041485960 cites W2046577405 @default.
• W2041485960 cites W2053403711 @default.
• W2041485960 cites W2055154941 @default.
• W2041485960 cites W2056143966 @default.
• W2041485960 cites W2063816440 @default.
• W2041485960 cites W2089448236 @default.
• W2041485960 cites W2094663537 @default.
• W2041485960 cites W2095643532 @default.
• W2041485960 cites W2098781753 @default.
• W2041485960 cites W2100522747 @default.
• W2041485960 cites W2101833157 @default.
• W2041485960 cites W2103459879 @default.
• W2041485960 cites W2124277850 @default.
• W2041485960 cites W2124944508 @default.
• W2041485960 cites W2134404166 @default.
• W2041485960 cites W2138284300 @default.
• W2041485960 cites W2145367747 @default.
• W2041485960 cites W2149563921 @default.
• W2041485960 cites W2152113072 @default.
• W2041485960 cites W2156375592 @default.
• W2041485960 cites W2161763613 @default.
• W2041485960 cites W2162443647 @default.
• W2041485960 cites W2614623345 @default.
• W2041485960 doi "https://doi.org/10.4161/cbt.7.10.6565" @default.
• W2041485960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18769116" @default.
• W2041485960 hasPublicationYear "2008" @default.
• W2041485960 type Work @default.
• W2041485960 sameAs 2041485960 @default.
• W2041485960 citedByCount "63" @default.
• W2041485960 countsByYear W20414859602012 @default.
• W2041485960 countsByYear W20414859602013 @default.
• W2041485960 countsByYear W20414859602014 @default.
• W2041485960 countsByYear W20414859602015 @default.
• W2041485960 countsByYear W20414859602016 @default.
• W2041485960 countsByYear W20414859602017 @default.
• W2041485960 countsByYear W20414859602018 @default.
• W2041485960 countsByYear W20414859602019 @default.
• W2041485960 countsByYear W20414859602020 @default.
• W2041485960 countsByYear W20414859602021 @default.
• W2041485960 countsByYear W20414859602022 @default.
• W2041485960 countsByYear W20414859602023 @default.
• W2041485960 crossrefType "journal-article" @default.
• W2041485960 hasAuthorship W2041485960A5017260307 @default.
• W2041485960 hasAuthorship W2041485960A5033774772 @default.
• W2041485960 hasAuthorship W2041485960A5043757838 @default.
• W2041485960 hasAuthorship W2041485960A5077351183 @default.
• W2041485960 hasAuthorship W2041485960A5090743176 @default.
• W2041485960 hasBestOaLocation W20414859601 @default.
• W2041485960 hasConcept C104317684 @default.
• W2041485960 hasConcept C120821319 @default.
• W2041485960 hasConcept C121608353 @default.
• W2041485960 hasConcept C124942203 @default.
• W2041485960 hasConcept C141231307 @default.
• W2041485960 hasConcept C150194340 @default.
• W2041485960 hasConcept C153911025 @default.
• W2041485960 hasConcept C186836561 @default.
• W2041485960 hasConcept C203014093 @default.
• W2041485960 hasConcept C204232928 @default.
• W2041485960 hasConcept C2780210213 @default.
• W2041485960 hasConcept C2909925829 @default.
• W2041485960 hasConcept C2992026798 @default.
• W2041485960 hasConcept C502942594 @default.
• W2041485960 hasConcept C54355233 @default.
• W2041485960 hasConcept C555283112 @default.
• W2041485960 hasConcept C7602840 @default.
• W2041485960 hasConcept C86339819 @default.
• W2041485960 hasConcept C86803240 @default.
• W2041485960 hasConceptScore W2041485960C104317684 @default.
• W2041485960 hasConceptScore W2041485960C120821319 @default.
• W2041485960 hasConceptScore W2041485960C121608353 @default.
• W2041485960 hasConceptScore W2041485960C124942203 @default.
• W2041485960 hasConceptScore W2041485960C141231307 @default.
• W2041485960 hasConceptScore W2041485960C150194340 @default.
• W2041485960 hasConceptScore W2041485960C153911025 @default.

• next