Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041490805> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2041490805 abstract "The influence of polyphosphorylated compounds on intoxication of human lung fibroblasts with Clostridium difficile toxin B was studied. ATP, as well as other nucleoside di-, tri-, and tetraphosphates, inorganic polyphosphates and polyphosphorylated sugars, caused a dose-dependent (1-5 mM range) delay in the appearance of the cytopathogenic effect. With a longer phosphate chain, the delay was more pronounced, although the cytopathogenic effect always developed finally, reaching the level of the control within 20 h. Toxin preparations contained one fraction of molecules able to bind ATP, besides one non-binding fraction. The protective effect of ATP did not depend on its energy producing ability. Neither was the protective effect due to an inactivation of the toxin per se, or to an interference with binding of the toxin to the cells. ATP was protective even upon addition 10 min after the toxin binding step. In the presence of ATP, the toxin remained accessible to neutralization with antitoxin. In analogy with the P-site on diphtheria toxin, we postulate that C. difficile toxin B contains a polyphosphate-binding site. This site is separate from the receptor-binding site, but involved in the interaction of toxin B with the cell surface shortly after the binding step." @default.
- W2041490805 created "2016-06-24" @default.
- W2041490805 creator A5026891781 @default.
- W2041490805 creator A5082409880 @default.
- W2041490805 date "1984-10-01" @default.
- W2041490805 modified "2023-10-02" @default.
- W2041490805 title "Polyphosphate-mediated protection from cellular intoxication with Clostridium difficile toxin B" @default.
- W2041490805 cites W1503112802 @default.
- W2041490805 cites W1510488434 @default.
- W2041490805 cites W1631834785 @default.
- W2041490805 cites W1851871464 @default.
- W2041490805 cites W1883805043 @default.
- W2041490805 cites W1916725939 @default.
- W2041490805 cites W1942228758 @default.
- W2041490805 cites W1969228260 @default.
- W2041490805 cites W2007204375 @default.
- W2041490805 cites W2027819223 @default.
- W2041490805 cites W2080409308 @default.
- W2041490805 cites W2161560210 @default.
- W2041490805 cites W2296326902 @default.
- W2041490805 doi "https://doi.org/10.1016/0167-4889(84)90159-9" @default.
- W2041490805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6487657" @default.
- W2041490805 hasPublicationYear "1984" @default.
- W2041490805 type Work @default.
- W2041490805 sameAs 2041490805 @default.
- W2041490805 citedByCount "13" @default.
- W2041490805 countsByYear W20414908052016 @default.
- W2041490805 crossrefType "journal-article" @default.
- W2041490805 hasAuthorship W2041490805A5026891781 @default.
- W2041490805 hasAuthorship W2041490805A5082409880 @default.
- W2041490805 hasConcept C107824862 @default.
- W2041490805 hasConcept C134193097 @default.
- W2041490805 hasConcept C181199279 @default.
- W2041490805 hasConcept C185592680 @default.
- W2041490805 hasConcept C2777132085 @default.
- W2041490805 hasConcept C2777367657 @default.
- W2041490805 hasConcept C2778038992 @default.
- W2041490805 hasConcept C2778973234 @default.
- W2041490805 hasConcept C2779564974 @default.
- W2041490805 hasConcept C2994496256 @default.
- W2041490805 hasConcept C33057221 @default.
- W2041490805 hasConcept C45510557 @default.
- W2041490805 hasConcept C501593827 @default.
- W2041490805 hasConcept C55493867 @default.
- W2041490805 hasConcept C75520062 @default.
- W2041490805 hasConcept C86803240 @default.
- W2041490805 hasConcept C89423630 @default.
- W2041490805 hasConcept C97505648 @default.
- W2041490805 hasConceptScore W2041490805C107824862 @default.
- W2041490805 hasConceptScore W2041490805C134193097 @default.
- W2041490805 hasConceptScore W2041490805C181199279 @default.
- W2041490805 hasConceptScore W2041490805C185592680 @default.
- W2041490805 hasConceptScore W2041490805C2777132085 @default.
- W2041490805 hasConceptScore W2041490805C2777367657 @default.
- W2041490805 hasConceptScore W2041490805C2778038992 @default.
- W2041490805 hasConceptScore W2041490805C2778973234 @default.
- W2041490805 hasConceptScore W2041490805C2779564974 @default.
- W2041490805 hasConceptScore W2041490805C2994496256 @default.
- W2041490805 hasConceptScore W2041490805C33057221 @default.
- W2041490805 hasConceptScore W2041490805C45510557 @default.
- W2041490805 hasConceptScore W2041490805C501593827 @default.
- W2041490805 hasConceptScore W2041490805C55493867 @default.
- W2041490805 hasConceptScore W2041490805C75520062 @default.
- W2041490805 hasConceptScore W2041490805C86803240 @default.
- W2041490805 hasConceptScore W2041490805C89423630 @default.
- W2041490805 hasConceptScore W2041490805C97505648 @default.
- W2041490805 hasLocation W20414908051 @default.
- W2041490805 hasLocation W20414908052 @default.
- W2041490805 hasOpenAccess W2041490805 @default.
- W2041490805 hasPrimaryLocation W20414908051 @default.
- W2041490805 hasRelatedWork W1004173637 @default.
- W2041490805 hasRelatedWork W13706259 @default.
- W2041490805 hasRelatedWork W1588017831 @default.
- W2041490805 hasRelatedWork W2007506862 @default.
- W2041490805 hasRelatedWork W2009123121 @default.
- W2041490805 hasRelatedWork W2041490805 @default.
- W2041490805 hasRelatedWork W2055433243 @default.
- W2041490805 hasRelatedWork W2057271309 @default.
- W2041490805 hasRelatedWork W2095270773 @default.
- W2041490805 hasRelatedWork W2145793351 @default.
- W2041490805 isParatext "false" @default.
- W2041490805 isRetracted "false" @default.
- W2041490805 magId "2041490805" @default.
- W2041490805 workType "article" @default.