Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041503707> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2041503707 endingPage "145" @default.
- W2041503707 startingPage "143" @default.
- W2041503707 abstract "Trenbolone, as a growth promoter in animal agriculture, has become an environmental androgen in surface water. Here, we aimed to reveal the effects of 17β-trenbolone on survival, growth, and gonadal differentiation in the frog Pelophylax nigromaculatus, which is widespread in East Asia and undergoing population decline. P. nigromaculatus tadpoles were exposed to 17β-trenbolone (0.1, 1, 10 μg/L) from Gosner stage 24/25 to complete metamorphosis. We found that 17β-trenbolone resulted in significantly high mortality in a concentration-dependent manner, with a decrease in body weight in the high concentration group compared with the solvent control. Based on gross gonadal morphology, no females were observed, instead of about 15% ambiguous sexes and 85% males, in all 17β-trenbolone treatment groups. Like normal testes, the gonads with sex-ambiguous morphology exhibited testicular histology, showing that the sex-ambiguous gonads were incomplete ovary-to-testis reversals (IOTTRs) with certain ovarian morphological features. In the IOTTRs, the transcriptional levels of ovary-biased genes decreased drastically relative to normal ovaries, and even declined to the levels in normal testes. These observations confirmed that all test concentrations of 17β-trenbolone resulted in 100% sex reversal, although some sex-reversed testes retained some ovarian characteristics at the morphological level. To our knowledge, this is the first report strongly demonstrating that trenbolone can cause female-to-male reversal in amphibians. Given that the lowest concentration tested is environmentally relevant, our study highlights the risks of trenbolone and other environmental androgens for P. nigromaculatus and other amphibians, in particular the species with high sensitivity of gonadal differentiation to androgenic chemicals." @default.
- W2041503707 created "2016-06-24" @default.
- W2041503707 creator A5056842246 @default.
- W2041503707 creator A5077738710 @default.
- W2041503707 creator A5085081461 @default.
- W2041503707 date "1970-07-01" @default.
- W2041503707 modified "2023-10-18" @default.
- W2041503707 title "Tautomerism of the anticodon base and the code degeneracy" @default.
- W2041503707 cites W2012061006 @default.
- W2041503707 cites W2052441903 @default.
- W2041503707 cites W2058433168 @default.
- W2041503707 cites W2066711410 @default.
- W2041503707 cites W2068292973 @default.
- W2041503707 cites W2068694787 @default.
- W2041503707 cites W2086124825 @default.
- W2041503707 cites W2315970429 @default.
- W2041503707 doi "https://doi.org/10.1016/0022-5193(70)90069-x" @default.
- W2041503707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5471466" @default.
- W2041503707 hasPublicationYear "1970" @default.
- W2041503707 type Work @default.
- W2041503707 sameAs 2041503707 @default.
- W2041503707 citedByCount "5" @default.
- W2041503707 crossrefType "journal-article" @default.
- W2041503707 hasAuthorship W2041503707A5056842246 @default.
- W2041503707 hasAuthorship W2041503707A5077738710 @default.
- W2041503707 hasAuthorship W2041503707A5085081461 @default.
- W2041503707 hasConcept C126322002 @default.
- W2041503707 hasConcept C134018914 @default.
- W2041503707 hasConcept C136397037 @default.
- W2041503707 hasConcept C137487509 @default.
- W2041503707 hasConcept C173758957 @default.
- W2041503707 hasConcept C18903297 @default.
- W2041503707 hasConcept C2777911890 @default.
- W2041503707 hasConcept C2778324911 @default.
- W2041503707 hasConcept C2779279991 @default.
- W2041503707 hasConcept C2781471917 @default.
- W2041503707 hasConcept C2908647359 @default.
- W2041503707 hasConcept C71315377 @default.
- W2041503707 hasConcept C71924100 @default.
- W2041503707 hasConcept C86803240 @default.
- W2041503707 hasConcept C90856448 @default.
- W2041503707 hasConcept C99454951 @default.
- W2041503707 hasConceptScore W2041503707C126322002 @default.
- W2041503707 hasConceptScore W2041503707C134018914 @default.
- W2041503707 hasConceptScore W2041503707C136397037 @default.
- W2041503707 hasConceptScore W2041503707C137487509 @default.
- W2041503707 hasConceptScore W2041503707C173758957 @default.
- W2041503707 hasConceptScore W2041503707C18903297 @default.
- W2041503707 hasConceptScore W2041503707C2777911890 @default.
- W2041503707 hasConceptScore W2041503707C2778324911 @default.
- W2041503707 hasConceptScore W2041503707C2779279991 @default.
- W2041503707 hasConceptScore W2041503707C2781471917 @default.
- W2041503707 hasConceptScore W2041503707C2908647359 @default.
- W2041503707 hasConceptScore W2041503707C71315377 @default.
- W2041503707 hasConceptScore W2041503707C71924100 @default.
- W2041503707 hasConceptScore W2041503707C86803240 @default.
- W2041503707 hasConceptScore W2041503707C90856448 @default.
- W2041503707 hasConceptScore W2041503707C99454951 @default.
- W2041503707 hasIssue "1" @default.
- W2041503707 hasLocation W20415037071 @default.
- W2041503707 hasLocation W20415037072 @default.
- W2041503707 hasOpenAccess W2041503707 @default.
- W2041503707 hasPrimaryLocation W20415037071 @default.
- W2041503707 hasRelatedWork W1965833776 @default.
- W2041503707 hasRelatedWork W1977493149 @default.
- W2041503707 hasRelatedWork W1979452793 @default.
- W2041503707 hasRelatedWork W1981433740 @default.
- W2041503707 hasRelatedWork W1986311037 @default.
- W2041503707 hasRelatedWork W2000206763 @default.
- W2041503707 hasRelatedWork W2053247908 @default.
- W2041503707 hasRelatedWork W2083564258 @default.
- W2041503707 hasRelatedWork W2089368232 @default.
- W2041503707 hasRelatedWork W2171330084 @default.
- W2041503707 hasVolume "28" @default.
- W2041503707 isParatext "false" @default.
- W2041503707 isRetracted "false" @default.
- W2041503707 magId "2041503707" @default.
- W2041503707 workType "article" @default.