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- W2041506816 abstract "In this study, a novel naphthalimide derivative 7c was designed which is topo II inhibiting though owning weak DNA binders. It was shown that 7c could induce cancer cells apoptosis and have less cytotoxicity in normal human cell. Further investigations on Hela cells revealed that 7c could also induce ROS generation, lysosome rupture as well as cathepsin B release. Subsequent mitochondrial damages including mitochondrial membrane permeabilization and the release of cytochrome c were also found in 7c when treating with Hela cells. According to our data, 7c may act as a lead compound for potential anticancer drugs. The idea of naphthalimides modification may also provide a novel strategy for naphthalimides design." @default.
- W2041506816 created "2016-06-24" @default.
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- W2041506816 date "2013-06-01" @default.
- W2041506816 modified "2023-10-18" @default.
- W2041506816 title "A ROS-mediated lysosomal–mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells" @default.
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- W2041506816 doi "https://doi.org/10.1016/j.canlet.2013.01.038" @default.
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