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• W2041508030 endingPage "576" @default.
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• W2041508030 abstract "Gene transfer to hematopoietic cells for the purpose of gene therapy is a new and rapidly developing field with clinical trials in progress. A fundamental goal of research in this field is the incorporation of exogenous genes into the chromosomes of the most primitive hematopoietic progenitor cells--stem cells. Recombinantly engineered retroviral vectors are the best characterized and are currently the only vector type in clinical trials directed at the hematopoietic system. High efficiency gene transfer and expression in murine stem cells and their progeny is now routine, but in larger animal models such as dogs or primates and preliminary clinical trials, gene transfer has been less successful. Problems such as retroviral efficiency, gene expression, insertional mutagenesis and helper virus contamination are being addressed. A promising new vector, the adeno-associated virus (AAV), has shown promise and may allow production of high titer, stable, recombinant virions without helper contamination and with potentially better safety parameters. However, the technology for AAV gene transfer is currently underdeveloped, and issues related to the reproducible production of vectors must be addressed. Other non-viral vector systems are being explored, but little data are available on applications to hematopoietic cells. Better preclinical models are needed to study gene targeting and expression in human cells. An overview of recombinant retroviral and adeno-associated viral vector production, preclinical data and preliminary clinical data will be given, and problems needing to be addressed at all stages of development before broad clinical utility can be achieved will be discussed." @default.
• W2041508030 created "2016-06-24" @default.
• W2041508030 creator A5017909971 @default.
• W2041508030 creator A5061090159 @default.
• W2041508030 date "1994-01-01" @default.
• W2041508030 modified "2023-10-02" @default.
• W2041508030 title "Gene transfer into hematopoietic progenitor and stem cells: Progress and problems" @default.
• W2041508030 cites W126651838 @default.
• W2041508030 cites W142531604 @default.
• W2041508030 cites W1490517254 @default.
• W2041508030 cites W1554330891 @default.
• W2041508030 cites W1584828020 @default.
• W2041508030 cites W16036224 @default.
• W2041508030 cites W1645190013 @default.
• W2041508030 cites W1750539994 @default.
• W2041508030 cites W1761899083 @default.
• W2041508030 cites W1875262379 @default.
• W2041508030 cites W1966423711 @default.
• W2041508030 cites W1966482743 @default.
• W2041508030 cites W1977152358 @default.
• W2041508030 cites W1985192507 @default.
• W2041508030 cites W1993702378 @default.
• W2041508030 cites W1994901592 @default.
• W2041508030 cites W1997582694 @default.
• W2041508030 cites W2003794641 @default.
• W2041508030 cites W2005920135 @default.
• W2041508030 cites W2008634652 @default.
• W2041508030 cites W2010671928 @default.
• W2041508030 cites W2013534167 @default.
• W2041508030 cites W2014687982 @default.
• W2041508030 cites W2016176753 @default.
• W2041508030 cites W2016647073 @default.
• W2041508030 cites W2022205235 @default.
• W2041508030 cites W2028272667 @default.
• W2041508030 cites W2028592334 @default.
• W2041508030 cites W2042021736 @default.
• W2041508030 cites W2044373221 @default.
• W2041508030 cites W2047099797 @default.
• W2041508030 cites W2052129340 @default.
• W2041508030 cites W2057436316 @default.
• W2041508030 cites W2058416269 @default.
• W2041508030 cites W2060015200 @default.
• W2041508030 cites W2060654428 @default.
• W2041508030 cites W2061120310 @default.
• W2041508030 cites W206238033 @default.
• W2041508030 cites W2063947819 @default.
• W2041508030 cites W2066775614 @default.
• W2041508030 cites W2066790739 @default.
• W2041508030 cites W2067379696 @default.
• W2041508030 cites W2082652927 @default.
• W2041508030 cites W2088108454 @default.
• W2041508030 cites W2094657382 @default.
• W2041508030 cites W2103872763 @default.
• W2041508030 cites W2105007068 @default.
• W2041508030 cites W2108471671 @default.
• W2041508030 cites W2111759041 @default.
• W2041508030 cites W2117460367 @default.
• W2041508030 cites W2120080045 @default.
• W2041508030 cites W2121944814 @default.
• W2041508030 cites W2125667082 @default.
• W2041508030 cites W2129851949 @default.
• W2041508030 cites W2129924213 @default.
• W2041508030 cites W2131430075 @default.
• W2041508030 cites W2132859839 @default.
• W2041508030 cites W2136159343 @default.
• W2041508030 cites W2150951349 @default.
• W2041508030 cites W2162992800 @default.
• W2041508030 cites W2168780184 @default.
• W2041508030 cites W2172238481 @default.
• W2041508030 cites W2182633717 @default.
• W2041508030 cites W2242711566 @default.
• W2041508030 cites W2270657113 @default.
• W2041508030 cites W2298126938 @default.
• W2041508030 cites W231718472 @default.
• W2041508030 cites W2321689187 @default.
• W2041508030 cites W2338577546 @default.
• W2041508030 cites W2403119620 @default.
• W2041508030 cites W2403853262 @default.
• W2041508030 cites W2413131581 @default.
• W2041508030 cites W2414665599 @default.
• W2041508030 cites W2415657389 @default.
• W2041508030 cites W2424735538 @default.
• W2041508030 cites W2439269229 @default.
• W2041508030 cites W254501375 @default.
• W2041508030 cites W27196345 @default.
• W2041508030 cites W4206471768 @default.
• W2041508030 cites W4229992754 @default.
• W2041508030 cites W4240056768 @default.
• W2041508030 cites W4245539712 @default.
• W2041508030 cites W4248229196 @default.
• W2041508030 cites W4249209568 @default.
• W2041508030 cites W4252005937 @default.
• W2041508030 cites W4253533771 @default.
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• W2041508030 doi "https://doi.org/10.1002/stem.5530120604" @default.
• W2041508030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7881358" @default.
• W2041508030 hasPublicationYear "1994" @default.
• W2041508030 type Work @default.

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