Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041508323> ?p ?o ?g. }
- W2041508323 endingPage "173" @default.
- W2041508323 startingPage "160" @default.
- W2041508323 abstract "Human respiratory syncytial virus (HRSV) P protein, 241 amino acid long, is a structural homotetrameric phosphoprotein. Viral transcription and replication processes are dependent on functional P protein interactions inside viral ribonucleoprotein complexes (RNPs). Binding capacity to RNPs proteins and transcription and replication complementation analyses, using inactive P protein variants, have identified residues essential for functional interactions with itself, L, N and M2-1 proteins. P protein may establish some of these interactions as monomer, but efficient viral transcription and replication requires P protein oligomerization through the central region of the molecule. A structurally stable three-dimensional model has been generated in silico for this region (residues 98-158). Our analysis has indicated that P protein residues L135, D139, E140 and L142 are involved in homotetramerization. Additionally, the residues D136, S156, T160 and E179 appear to be essential for P protein activity on viral RNA synthesis and very high turnover phosphorylation at S143, T160 and T210 could regulate it. Thus, compounds targeted to those of these residues, located in the modeled three-dimensional structure, could have specific anti-HRSV effect." @default.
- W2041508323 created "2016-06-24" @default.
- W2041508323 creator A5028972631 @default.
- W2041508323 creator A5050506339 @default.
- W2041508323 creator A5061201501 @default.
- W2041508323 creator A5084350139 @default.
- W2041508323 date "2008-03-01" @default.
- W2041508323 modified "2023-09-26" @default.
- W2041508323 title "Residues in human respiratory syncytial virus P protein that are essential for its activity on RNA viral synthesis" @default.
- W2041508323 cites W1496194117 @default.
- W2041508323 cites W1595880282 @default.
- W2041508323 cites W1597676159 @default.
- W2041508323 cites W1600427234 @default.
- W2041508323 cites W1769966102 @default.
- W2041508323 cites W1869944834 @default.
- W2041508323 cites W1974451794 @default.
- W2041508323 cites W1981825290 @default.
- W2041508323 cites W1986135139 @default.
- W2041508323 cites W2006805319 @default.
- W2041508323 cites W2008759459 @default.
- W2041508323 cites W2015642465 @default.
- W2041508323 cites W2034271636 @default.
- W2041508323 cites W2049724155 @default.
- W2041508323 cites W2055043387 @default.
- W2041508323 cites W2055357560 @default.
- W2041508323 cites W2056520017 @default.
- W2041508323 cites W2057761745 @default.
- W2041508323 cites W2060809301 @default.
- W2041508323 cites W2068160897 @default.
- W2041508323 cites W2068827812 @default.
- W2041508323 cites W2079742205 @default.
- W2041508323 cites W2084466582 @default.
- W2041508323 cites W2088933990 @default.
- W2041508323 cites W2100544994 @default.
- W2041508323 cites W2105881372 @default.
- W2041508323 cites W2106882534 @default.
- W2041508323 cites W2115225611 @default.
- W2041508323 cites W2118280608 @default.
- W2041508323 cites W2125725297 @default.
- W2041508323 cites W2131089277 @default.
- W2041508323 cites W2132717858 @default.
- W2041508323 cites W2137165958 @default.
- W2041508323 cites W2144362290 @default.
- W2041508323 cites W2145497813 @default.
- W2041508323 cites W2153861528 @default.
- W2041508323 cites W2154614767 @default.
- W2041508323 cites W2162323014 @default.
- W2041508323 cites W2165024752 @default.
- W2041508323 cites W2171136535 @default.
- W2041508323 cites W2181977126 @default.
- W2041508323 cites W2182822260 @default.
- W2041508323 doi "https://doi.org/10.1016/j.virusres.2007.11.013" @default.
- W2041508323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18179840" @default.
- W2041508323 hasPublicationYear "2008" @default.
- W2041508323 type Work @default.
- W2041508323 sameAs 2041508323 @default.
- W2041508323 citedByCount "20" @default.
- W2041508323 countsByYear W20415083232012 @default.
- W2041508323 countsByYear W20415083232013 @default.
- W2041508323 countsByYear W20415083232014 @default.
- W2041508323 countsByYear W20415083232015 @default.
- W2041508323 countsByYear W20415083232016 @default.
- W2041508323 countsByYear W20415083232017 @default.
- W2041508323 countsByYear W20415083232018 @default.
- W2041508323 countsByYear W20415083232019 @default.
- W2041508323 countsByYear W20415083232021 @default.
- W2041508323 countsByYear W20415083232022 @default.
- W2041508323 crossrefType "journal-article" @default.
- W2041508323 hasAuthorship W2041508323A5028972631 @default.
- W2041508323 hasAuthorship W2041508323A5050506339 @default.
- W2041508323 hasAuthorship W2041508323A5061201501 @default.
- W2041508323 hasAuthorship W2041508323A5084350139 @default.
- W2041508323 hasConcept C104317684 @default.
- W2041508323 hasConcept C10852380 @default.
- W2041508323 hasConcept C11960822 @default.
- W2041508323 hasConcept C138885662 @default.
- W2041508323 hasConcept C140704245 @default.
- W2041508323 hasConcept C153911025 @default.
- W2041508323 hasConcept C159047783 @default.
- W2041508323 hasConcept C179926584 @default.
- W2041508323 hasConcept C2522874641 @default.
- W2041508323 hasConcept C25897203 @default.
- W2041508323 hasConcept C2777061661 @default.
- W2041508323 hasConcept C2780879997 @default.
- W2041508323 hasConcept C41895202 @default.
- W2041508323 hasConcept C55493867 @default.
- W2041508323 hasConcept C58475186 @default.
- W2041508323 hasConcept C67705224 @default.
- W2041508323 hasConcept C75934600 @default.
- W2041508323 hasConcept C86803240 @default.
- W2041508323 hasConcept C95444343 @default.
- W2041508323 hasConceptScore W2041508323C104317684 @default.
- W2041508323 hasConceptScore W2041508323C10852380 @default.
- W2041508323 hasConceptScore W2041508323C11960822 @default.
- W2041508323 hasConceptScore W2041508323C138885662 @default.
- W2041508323 hasConceptScore W2041508323C140704245 @default.
- W2041508323 hasConceptScore W2041508323C153911025 @default.
- W2041508323 hasConceptScore W2041508323C159047783 @default.