Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041521527> ?p ?o ?g. }
- W2041521527 endingPage "353" @default.
- W2041521527 startingPage "338" @default.
- W2041521527 abstract "Hypoxia worsens brain injury following trauma, but the mechanisms remain unclear. The purpose of this study was to determine the effect of traumatic brain injury (TBI) and secondary hypoxia (9% oxygen) on apoptosis-related protein expression, cell death, and behavior. Using a murine weight-drop model, TBI led to an early (6 h) increase followed by a later (24 h) decrease in neuronal apoptosis inhibitor protein (NAIP) expression in the olfactory and motor cortex; in contrast, TBI led to a sustained (6 h to 7 days) increase in NAIP in the striatum. The peak increase in the expression of NAIP (6-12 h) following TBI alone was delayed (1-7 days) when hypoxia was added to TBI. Hypoxia following TBI further depleted other apoptosis inhibitor proteins (IAPs) and activated caspases, as well as increased contusion size and worsened cell death. Hypoxia added to TBI also increased motor and feeding activity on days 2 and 4 compared to TBI alone. Hypoxia without TBI had no effect on the expression of IAPs or cell death. These findings show that IAPs have a potential role in the increased vulnerability of brain cells to hypoxia following TBI, and have implications for configuring future therapies for TBI." @default.
- W2041521527 created "2016-06-24" @default.
- W2041521527 creator A5014077903 @default.
- W2041521527 creator A5017509573 @default.
- W2041521527 creator A5018073431 @default.
- W2041521527 creator A5019604864 @default.
- W2041521527 creator A5025051455 @default.
- W2041521527 creator A5027246988 @default.
- W2041521527 creator A5048034960 @default.
- W2041521527 creator A5059074382 @default.
- W2041521527 creator A5067359233 @default.
- W2041521527 creator A5086208674 @default.
- W2041521527 date "2007-02-01" @default.
- W2041521527 modified "2023-09-27" @default.
- W2041521527 title "Hypoxia Alters The Expression of Inhibitor of Apoptosis Proteins after Brain Trauma in The Mouse" @default.
- W2041521527 cites W1522782595 @default.
- W2041521527 cites W1542946250 @default.
- W2041521527 cites W1568752613 @default.
- W2041521527 cites W1584761909 @default.
- W2041521527 cites W1966704219 @default.
- W2041521527 cites W1972966488 @default.
- W2041521527 cites W1973323192 @default.
- W2041521527 cites W1988318115 @default.
- W2041521527 cites W1989626351 @default.
- W2041521527 cites W1993889646 @default.
- W2041521527 cites W1998956779 @default.
- W2041521527 cites W2010945173 @default.
- W2041521527 cites W2022647670 @default.
- W2041521527 cites W2027416773 @default.
- W2041521527 cites W2028263965 @default.
- W2041521527 cites W2028592029 @default.
- W2041521527 cites W2030204664 @default.
- W2041521527 cites W2031413466 @default.
- W2041521527 cites W2042341827 @default.
- W2041521527 cites W2056770408 @default.
- W2041521527 cites W2060582701 @default.
- W2041521527 cites W2061497413 @default.
- W2041521527 cites W2063072318 @default.
- W2041521527 cites W2067469346 @default.
- W2041521527 cites W2082606474 @default.
- W2041521527 cites W2083906562 @default.
- W2041521527 cites W2084962044 @default.
- W2041521527 cites W2085652982 @default.
- W2041521527 cites W2086353424 @default.
- W2041521527 cites W2086591801 @default.
- W2041521527 cites W2087788920 @default.
- W2041521527 cites W2090838854 @default.
- W2041521527 cites W2093879881 @default.
- W2041521527 cites W2127764891 @default.
- W2041521527 cites W2133879302 @default.
- W2041521527 cites W2137832426 @default.
- W2041521527 cites W2158799442 @default.
- W2041521527 cites W2167490100 @default.
- W2041521527 cites W2169201834 @default.
- W2041521527 cites W2171902246 @default.
- W2041521527 cites W2330153913 @default.
- W2041521527 cites W84628867 @default.
- W2041521527 doi "https://doi.org/10.1089/neu.2006.003615" @default.
- W2041521527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17375998" @default.
- W2041521527 hasPublicationYear "2007" @default.
- W2041521527 type Work @default.
- W2041521527 sameAs 2041521527 @default.
- W2041521527 citedByCount "17" @default.
- W2041521527 countsByYear W20415215272012 @default.
- W2041521527 countsByYear W20415215272013 @default.
- W2041521527 countsByYear W20415215272014 @default.
- W2041521527 countsByYear W20415215272015 @default.
- W2041521527 countsByYear W20415215272016 @default.
- W2041521527 countsByYear W20415215272021 @default.
- W2041521527 crossrefType "journal-article" @default.
- W2041521527 hasAuthorship W2041521527A5014077903 @default.
- W2041521527 hasAuthorship W2041521527A5017509573 @default.
- W2041521527 hasAuthorship W2041521527A5018073431 @default.
- W2041521527 hasAuthorship W2041521527A5019604864 @default.
- W2041521527 hasAuthorship W2041521527A5025051455 @default.
- W2041521527 hasAuthorship W2041521527A5027246988 @default.
- W2041521527 hasAuthorship W2041521527A5048034960 @default.
- W2041521527 hasAuthorship W2041521527A5059074382 @default.
- W2041521527 hasAuthorship W2041521527A5067359233 @default.
- W2041521527 hasAuthorship W2041521527A5086208674 @default.
- W2041521527 hasConcept C118552586 @default.
- W2041521527 hasConcept C126322002 @default.
- W2041521527 hasConcept C134018914 @default.
- W2041521527 hasConcept C142724271 @default.
- W2041521527 hasConcept C169760540 @default.
- W2041521527 hasConcept C178790620 @default.
- W2041521527 hasConcept C185592680 @default.
- W2041521527 hasConcept C190283241 @default.
- W2041521527 hasConcept C2781017439 @default.
- W2041521527 hasConcept C2781458332 @default.
- W2041521527 hasConcept C31573885 @default.
- W2041521527 hasConcept C540031477 @default.
- W2041521527 hasConcept C55493867 @default.
- W2041521527 hasConcept C71924100 @default.
- W2041521527 hasConcept C7836513 @default.
- W2041521527 hasConcept C86803240 @default.
- W2041521527 hasConceptScore W2041521527C118552586 @default.
- W2041521527 hasConceptScore W2041521527C126322002 @default.