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- W2041521903 abstract "Let-7 and Lin28 establish a double-negative feedback loop to affect several biological processes, such as differentiation of stem cell, invasion and metastasis and tumorigenesis. In this study, we systematically investigated the associations between 6 potentially functional SNPs of let7 and Lin28 genes and the risk of oral cavity cancer with a case-control study including 384 oral cavity cancer cases and 731 controls. We found that the variant allele (T) of rs221636 of Lin28B was significantly associated with a reduced risk of oral cavity cancer [odds ratio (OR) = 0.73, 95% confidence interval (CI) = 0.58–0.92, P = 7.55 × 10−3 in additive model]. Bioinformatics prediction indicated that rs221636 was located at the binding site of hsa-miR-548p in the 3′ UTR of Lin28B. Luciferase activity assay also showed a lower expression level for rs221636 T allele compared with A allele. These findings indicated that rs221236 located at Lin28B may contribute to the risk of oral cavity cancer through the interruption of miRNA binding." @default.
- W2041521903 created "2016-06-24" @default.
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- W2041521903 date "2014-12-11" @default.
- W2041521903 modified "2023-10-18" @default.
- W2041521903 title "Genetic variants in let-7/Lin28 modulate the risk of oral cavity cancer in a Chinese Han Population" @default.
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- W2041521903 doi "https://doi.org/10.1038/srep07434" @default.
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