Matches in SemOpenAlex for { <https://semopenalex.org/work/W2041534319> ?p ?o ?g. }
- W2041534319 endingPage "84" @default.
- W2041534319 startingPage "74" @default.
- W2041534319 abstract "The relationship between tyrosine availability and high potassium (K+) induced dopamine (DA) and norepinephrine (NE) efflux was examined in striatum using in vivo microdialysis . High K+ (80 mM) was included in perfusate for two 30 min periods, 2.5 h apart. After the first high-K+ perfusion, a tyrosine- and phenylalanine-free mixture of large neutral amino acids (LNAA(−)) was administered (IP) to lower brain tyrosine. Tyrosine (0, 25, 50 or 100 mg/kg IP) was administered 30 min prior to the second high-K+ perfusion. The ratio of catecholamine efflux during the two perfusions (P2/P1) was compared between groups. LNAA(−) significantly lowered P2/P1 for both DA and NE. Tyrosine 25–50 mg/kg blocked the LNAA(−) effect. We conclude that catecholamine efflux during prolonged depolarization is tyrosine dependent. Analyses of LNAA levels suggest that availability of tyrosine for tyrosine hydroxylation may be modulated by competition between LNAAs within brain extracellular fluid." @default.
- W2041534319 created "2016-06-24" @default.
- W2041534319 creator A5040816899 @default.
- W2041534319 creator A5053425741 @default.
- W2041534319 creator A5085206739 @default.
- W2041534319 date "2008-05-01" @default.
- W2041534319 modified "2023-09-25" @default.
- W2041534319 title "Tyrosine availability modulates potassium-induced striatal catecholamine efflux in vivo" @default.
- W2041534319 cites W134599367 @default.
- W2041534319 cites W1419487761 @default.
- W2041534319 cites W1509932721 @default.
- W2041534319 cites W1517695502 @default.
- W2041534319 cites W1521916566 @default.
- W2041534319 cites W1547693568 @default.
- W2041534319 cites W1552613893 @default.
- W2041534319 cites W1553979887 @default.
- W2041534319 cites W1596611034 @default.
- W2041534319 cites W1895466054 @default.
- W2041534319 cites W1925183652 @default.
- W2041534319 cites W1968064550 @default.
- W2041534319 cites W1968933230 @default.
- W2041534319 cites W1969371951 @default.
- W2041534319 cites W1970680380 @default.
- W2041534319 cites W1972927648 @default.
- W2041534319 cites W1974500405 @default.
- W2041534319 cites W1975860153 @default.
- W2041534319 cites W1976150999 @default.
- W2041534319 cites W1977351196 @default.
- W2041534319 cites W1978404664 @default.
- W2041534319 cites W1980460020 @default.
- W2041534319 cites W1981664637 @default.
- W2041534319 cites W1981707089 @default.
- W2041534319 cites W1982470650 @default.
- W2041534319 cites W1984632558 @default.
- W2041534319 cites W1986671246 @default.
- W2041534319 cites W1987778679 @default.
- W2041534319 cites W1987823976 @default.
- W2041534319 cites W1988385174 @default.
- W2041534319 cites W1989388155 @default.
- W2041534319 cites W1991054305 @default.
- W2041534319 cites W1991701104 @default.
- W2041534319 cites W1992367051 @default.
- W2041534319 cites W1992398525 @default.
- W2041534319 cites W1992549174 @default.
- W2041534319 cites W1994684558 @default.
- W2041534319 cites W1996001867 @default.
- W2041534319 cites W1999867718 @default.
- W2041534319 cites W2005043730 @default.
- W2041534319 cites W2006051132 @default.
- W2041534319 cites W2007443737 @default.
- W2041534319 cites W2008659649 @default.
- W2041534319 cites W2009101569 @default.
- W2041534319 cites W2009594663 @default.
- W2041534319 cites W2009699988 @default.
- W2041534319 cites W2010397187 @default.
- W2041534319 cites W2014719919 @default.
- W2041534319 cites W2016751178 @default.
- W2041534319 cites W2019615219 @default.
- W2041534319 cites W2021574259 @default.
- W2041534319 cites W2022777313 @default.
- W2041534319 cites W2027211268 @default.
- W2041534319 cites W2028103147 @default.
- W2041534319 cites W2033877544 @default.
- W2041534319 cites W2035808401 @default.
- W2041534319 cites W2038399930 @default.
- W2041534319 cites W2039060155 @default.
- W2041534319 cites W2041575071 @default.
- W2041534319 cites W2043606223 @default.
- W2041534319 cites W2043779181 @default.
- W2041534319 cites W2044022880 @default.
- W2041534319 cites W2046368819 @default.
- W2041534319 cites W2052101718 @default.
- W2041534319 cites W2052908314 @default.
- W2041534319 cites W2054231808 @default.
- W2041534319 cites W2057084723 @default.
- W2041534319 cites W2058298319 @default.
- W2041534319 cites W2058423049 @default.
- W2041534319 cites W2060024030 @default.
- W2041534319 cites W2060128483 @default.
- W2041534319 cites W2062851237 @default.
- W2041534319 cites W2063465801 @default.
- W2041534319 cites W2064589036 @default.
- W2041534319 cites W2070197548 @default.
- W2041534319 cites W2076466670 @default.
- W2041534319 cites W2077332064 @default.
- W2041534319 cites W2081506893 @default.
- W2041534319 cites W2082205238 @default.
- W2041534319 cites W2082841504 @default.
- W2041534319 cites W2083308861 @default.
- W2041534319 cites W2084418963 @default.
- W2041534319 cites W2086172007 @default.
- W2041534319 cites W2086443386 @default.
- W2041534319 cites W2088919174 @default.
- W2041534319 cites W2092065659 @default.
- W2041534319 cites W2093177172 @default.
- W2041534319 cites W2093467598 @default.
- W2041534319 cites W2094047507 @default.
- W2041534319 cites W2095460819 @default.